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首页> 外文期刊>Rheumatology >Evaluation of ankylosing spondylitis quality of life questionnaire: Responsiveness of a new patient-reported outcome measure
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Evaluation of ankylosing spondylitis quality of life questionnaire: Responsiveness of a new patient-reported outcome measure

机译：强直性脊柱炎生活质量问卷的评估：一项新的患者报告的结局指标的反应性

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Objective: To determine the responsiveness and minimal important change (MIC) of Evaluation of Ankylosing Spondylitis Quality of Life (EASi-QoL), a reliable and valid patient-reported measure of AS-specific quality of life with four domains: physical function (PF), disease activity (DA), emotional well-being (EWB) and social participation (SP). Methods: A total of 1000 UK AS patients received a postal questionnaire including EASi-QoL. Comparative responsiveness of EASi-QoL was assessed against measures reflecting similar health domains in patients self-reporting an improvement in their AS-specific health at 6 months on a health transition question. Effect size (ES) statistics were calculated for all measures and MIC was determined for EASi-QoL. Comparative responsiveness was determined in a randomized trial of AS patients receiving etanercept (ETN) 50 mg weekly or SSZ 3 g daily. Results: Of 470 patients, 80 responding at 6 months reported health improvement. Responsiveness (ES) for EASi-QoL domains was superior or similar to comparator measures: DA 0.72 vs BASDAI 0.58; SP 0.52 vs SF-36 social functioning 0.29; PF 0.32 vs BASFI 0.28 and SF-36 PF 0.24; EWB 0.40 vs HADS-anxiety 0.13, HADS-depression 0.21 and SF-36 mental health 0.35. ES for the ASQoL was 0.40. Superior ES was seen in those improving somewhat. In the randomized trial, all EASi-QoL domains had superior responsiveness to comparator measures following ETN treatment. Following SSZ treatment, all EASi-QoL domains were highly responsive, but BASDAI and BASFI was more responsive than EASi-QoL(DA) and (PF), respectively. Conclusion: In patients reporting improvement during routine clinical practice or following treatment with ETN or SSZ, EASi-QoL domains have superior or comparable responsiveness than comparable measures.
机译：目的：确定强直性脊柱炎生活质量评估（EASi-QoL）的反应性和最小重要变化（MIC），这是可靠且有效的患者报告的AS特定生活质量评估指标，涉及以下四个方面：身体机能（PF） ），疾病活动（DA），情绪健康（EWB）和社会参与（SP）。方法：总共1000名英国AS患者接受了包括EASi-QoL在内的邮政问卷。 EASi-QoL的相对反应性是根据反映健康状况类似问题的措施进行评估的，这些措施反映了患者在自我健康过渡问题上六个月时自我报告的AS特定健康状况有所改善。计算所有措施的效应大小（ES）统计数据，并确定EASi-QoL的MIC。在每周接受50 mg依那西普（ETN）或每天3 g SSZ的AS患者的随机试验中，确定了比较反应性。结果：在470例患者中，有80例在6个月后缓解，报告健康状况得到改善。 EASi-QoL域的响应度（ES）优于或相似于比较指标：DA 0.72 vs BASDAI 0.58; SP 0.52 vs SF-36社交功能0.29; PF 0.32和BASFI 0.28和SF-36 PF 0.24; EWB为0.40，而HADS焦虑为0.13，HADS抑郁为0.21，SF-36心理健康为0.35。 ASQoL的ES为0.40。在那些有所改善的人中看到了优越的ES。在随机试验中，ETN治疗后，所有EASi-QoL结构域对比较指标的反应均较优。经过SSZ处理后，所有EASi-QoL域都具有高响应性，但BASDAI和BASFI的响应性分别高于EASi-QoL（DA）和（PF）。结论：在常规临床实践中或在接受ETN或SSZ治疗后报告有所改善的患者中，EASi-QoL域的反应性优于同类措施。

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