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首页> 外文期刊>Rheumatology >Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome.
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Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome.

机译：腮腺活检与唇部活检相比可诊断原发性干燥综合征。

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OBJECTIVE: To assess the value of the parotid biopsy as a diagnostic tool for primary Sjogren's syndrome (pSS), and to compare the parotid biopsy and the labial biopsy with regard to diagnostic value and biopsy-related morbidity. METHODS: In 15 consecutive patients with pSS and 20 controls, the parotid biopsy was assessed as a diagnostic tool based on the presence of lymphocytic foci, benign lymphoepithelial lesions and lymphoid follicles. These new histological criteria were compared with established diagnostic criteria for the labial biopsy in 35 consecutive patients suspected for pSS who underwent simultaneous biopsies from both sites. In addition, both biopsies were compared for morbidity. RESULTS: The first analysis revealed a focus score of >or=1 or lymphocytic infiltrates (not fulfilling the criterion of a focus score of 1) combined with benign lymphoepithelial lesions as diagnostic criteria for pSS. When comparing the parotid biopsy with the labial biopsy sensitivity and specificity were comparable (sensitivity 78%, specificity 86%). Level of pain was comparable and no loss of motor function was observed. No permanent sensory loss was observed after parotid biopsy, while labial biopsy led to permanent sensory loss in 6% of the patients. Malignant lymphoma was detected in one parotid biopsy by chance, without involvement of the labial salivary gland. CONCLUSION: A parotid biopsy has a diagnostic potential comparable with that of a labial biopsy in the diagnosis of pSS, and may be associated with less morbidity.
机译：目的：评估腮腺活检作为原发性干燥综合征（pSS）的诊断工具的价值，并比较腮腺活检和阴唇活检的诊断价值和与活检相关的发病率。方法：连续15例pSS患者和20例对照患者，根据是否存在淋巴细胞灶，良性淋巴上皮病变和淋巴滤泡，将腮腺活检评估为诊断工具。将这些新的组织学标准与已建立的连续35例怀疑患有pSS并同时从两个部位进行活检的患者进行阴唇活检的诊断标准进行了比较。另外，比较了两个活检的发病率。结果：第一项分析显示，病灶评分大于或等于1或淋巴细胞浸润（不符合病灶评分为1的标准）结合良性淋巴上皮病变作为pSS的诊断标准。当比较腮腺活检和阴唇活检时，敏感性和特异性相当（敏感性为78％，特异性为86％）。疼痛程度相当，没有观察到运动功能丧失。腮腺活检后未见永久性感觉丧失，而唇部活检导致6％的患者永久性感觉丧失。在一次腮腺活检中偶然发现恶性淋巴瘤，而没有唾液腺的累及。结论：腮腺活检在诊断pSS方面具有与唇部活检相当的诊断潜能，且发病率可能较低。

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