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首页> 外文期刊>Rheumatology >Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration.
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Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration.

机译：幼年特发性关节炎的淋巴新生与ANA阳性和浆细胞浸润相关。

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摘要

OBJECTIVE: The aim of the study was to evaluate the pattern of the lymphoid organization in the synovial tissue of patients affected with juvenile idiopathic arthritis (JIA). METHODS: A total of 40 JIA patients who underwent synoviectomy or synovial biopsies were enrolled. The mean age at surgery was 15.1 yrs (range 6-30 yrs) and the mean disease duration was 6.7 yrs (range 3 months to 22.2 yrs). Tissue specimens were grouped according to the following criteria: (i) diffuse perivascular infiltrate without lymphoid organization, (ii) T cell-B cell aggregates with or without germinal centre reaction. RESULTS: Synovial tissues from 12 JIA patients did not show any sign of lymphoid organization, whereas 28 patients displayed a variable number of T-B cell aggregates. Typical features consistent with a germinal centre reaction were present in two JIA patients only. Lymphoid organization in JIA patients did not correlate with the duration and severity of the disease or with the degree of synovial inflammation, but did positively correlate with the presence of anti-nuclear antibodies. Moreover, a diffuse lymphocyte infiltration was significantly related to the presence of an acute phase of inflammation and the presence of lymphoid aggregates correlated with the degree of plasma cells infiltration. CONCLUSIONS: Lymphoid neogenesis in JIA represents a phase in the immunopathological process that characterize the development of inflammatory synovitis. It is not related to disease activity or severity, but appears to be more frequent in patients with circulating anti-nuclear antibodies.
机译：目的：本研究旨在评估青少年特发性关节炎（JIA）患者滑膜组织中淋巴组织的分布模式。方法：共纳入40例行滑膜切除术或滑膜活检的JIA患者。手术的平均年龄为15.1岁（6-30岁），平均疾病持续时间为6.7岁（3个月至22.2岁）。根据以下标准对组织标本进行分组：（i）弥漫性血管周围浸润，无淋巴组织，（ii）有或没有生发中心反应的T细胞-B细胞聚集。结果：12例JIA患者的滑膜组织未显示任何淋巴样组织征象，而28例患者表现出可变数量的T-B细胞聚集体。仅在两名JIA患者中出现了与生发中心反应一致的典型特征。 JIA患者中的淋巴组织与疾病的持续时间，严重程度或滑膜炎症程度无关，但与抗核抗体的存在呈正相关。此外，弥漫性淋巴细胞浸润与炎症急性期的存在显着相关，并且淋巴样聚集体的存在与浆细胞浸润的程度相关。结论：JIA中的淋巴新生代表了免疫病理过程中炎症性滑膜炎发展的一个阶段。它与疾病的活动或严重程度无关，但是在循环中的抗核抗体患者中似乎更常见。

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