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首页> 外文期刊>Rheumatology >High incidence of severe ischaemic complications in patients with giant cell arteritis irrespective of platelet count and size, and platelet inhibition.
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High incidence of severe ischaemic complications in patients with giant cell arteritis irrespective of platelet count and size, and platelet inhibition.

机译：巨细胞性动脉炎患者严重缺血性并发症的发生率很高，而与血小板计数和大小以及血小板抑制作用无关。

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OBJECTIVE: Vision loss and ischaemic stroke are feared complications in GCA. We investigated how platelet count and size and platelet inhibition with ASA relate to ischaemic complications in patients with GCA. METHODS: Charts of patients with GCA were retrospectively analysed. Jaw claudication, amaurosis fugax, blurred vision, ischaemic stroke and permanent visual loss were classified as 'ischaemic events'; ischaemic stroke and permanent visual loss were sub-grouped as 'severe ischaemic events'. The incidence of ischaemia and the association to the pre-defined covariates age, fever, ESR, platelet count and size and ASA treatment were assessed. RESULTS: Eighty-five patients (mean age 73 yrs, 60% women, 78% biopsy-proven) were included in the analysis. Of the 85 patients, 62 (73%) presented with ischaemic events, 29/85 patients (34%) with severe ischaemic events. At the time of diagnosis 22/85 patients (26%) were treated with ASA. Of these 22 patients, 15 (68%) presented with ischaemic events, 7/22 patients (32%) with severe ischaemic events. In multivariate analysis, neither platelet count nor size or ASA treatment were significantly associated with ischaemic or severe ischaemic events. CONCLUSIONS: The incidence of severe ischaemic events in patients with GCA was high, irrespective of platelet count and size and established ASA treatment.
机译：目的：视力下降和缺血性中风是GCA的并发症。我们调查了ASA的血小板计数和大小以及血小板抑制与GCA患者的缺血性并发症之间的关系。方法：回顾性分析GCA患者的病历。下颌c行，黑桃病，视力模糊，缺血性中风和永久性视力丧失被归类为“缺血事件”。缺血性中风和永久性视力丧失被分为“严重缺血性事件”。评估缺血的发生率以及与预定义的年龄，发烧，ESR，血小板计数和大小以及ASA治疗的协变量之间的关系。结果：该研究纳入了85例患者（平均年龄73岁，女性60％，经活检证实为78％）。在85位患者中，有62位（73％）出现缺血事件，29/85位患者（34％）出现严重缺血事件。在诊断时，有22/85例患者（26％）接受了ASA治疗。在这22例患者中，有15例（68％）出现缺血事件，7/22例（32％）出现严重缺血事件。在多变量分析中，血小板计数，大小或ASA治疗均与缺血性或严重缺血性事件均无显着相关性。结论：GCA患者严重缺血事件的发生率较高，而与血小板计数和大小以及是否采用ASA治疗无关。

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