Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate

Sawant Ratnnadeep C.; Liao Ying-Ju; Lin Yi-Jyun; Badsara Satpal Singh; Luo Shun-Yuan

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Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate

机译：肝素和硫酸乙酰肝素的二糖重复单元（IdoA-GlcN）的形式合成

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A concise route to access the key disaccharide repeating unit (IdoA-GlcN) of heparan sulfate is described. The synthesis was accomplished by commercially available diacetone alpha-D-glucose to functional group transformations, which led to the formation of a L-iduronate donor. This L-iduronate donor was subsequently coupled with a glucosyl acceptor to form the corresponding key disaccharide repeating unit (IdoA-GlcN) of heparan sulfate in good overall yield.

机译：描述了访问硫酸乙酰肝素的关键二糖重复单元（IdoA-GlcN）的简洁途径。合成是通过商业上可获得的双丙酮α-D-葡萄糖向官能团的转化完成的，这导致了L-艾杜糖酸酯供体的形成。随后将该L-艾杜糖酸盐供体与葡糖基受体偶联以良好的总收率形成硫酸乙酰肝素的相应关键二糖重复单元（IdoA-GlcN）。

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《RSC Advances》 |2015年第25期|共7页
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Sawant Ratnnadeep C.; Liao Ying-Ju; Lin Yi-Jyun; Badsara Satpal Singh; Luo Shun-Yuan;
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正文语种 eng
中图分类化学;
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1. Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate [J] . Sawant Ratnnadeep C., Liao Ying-Ju, Lin Yi-Jyun, RSC Advances . 2015,第25期

机译：肝素和硫酸乙酰肝素的二糖重复单元（IdoA-GlcN）的形式合成
2. Synthesis of 48 disaccharide building blocks for the assembly of a heparin and heparan sulfate oligosaccharide library [J] . Lu LD, Shie CR, Kulkarni SS, Organic letters . 2006,第26期

机译：合成用于组装肝素和硫酸乙酰肝素寡糖文库的48种二糖结构单元
3. Synthesis of 48 disaccharide building blocks for the assembly of a heparin and heparan sulfate oligosaccharide library [J] . Lu LD, Shie CR, Kulkarni SS, Organic letters . 2006,第26期

机译：合成用于组装肝素和硫酸乙酰肝素寡糖文库的48种二糖结构单元
4. Method Development for the Comprehensive Compositional Analysis of Heparin/Heparan Sulfate Disaccharides from Human Serum [C] . Wei Wei, Milady R. Ninonuevo, Lieza M. Danan-Leon, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：人血清肝素/硫酸乙酰肝素二糖综合组成分析的方法开发
5. Applications of Heparin and Heparan Sulfate Oligosaccharides Prepared by Chemoenzymatic Synthesis [D] . Arnold, Katelyn M. 2019

机译：化学酶合成制备的肝素和肝素硫酸糖寡糖的应用
6. Towards the assembly of heparin and heparan sulfate oligosaccharide libraries: efficient synthesis of uronic acid and disaccharide building blocks [O] . Akihiro Saito, Masahiro Wakao, Hiroshi Deguchi, -1

机译：朝向肝素和硫酸普乙肝素寡糖文库的组装：有效合成尿酸和二糖构造块
7. Toward the assembly of heparin and heparan sulfate oligosaccharide libraries: efficient synthesis of uronic acid and disaccharide building blocks [O] . Akihiro Saito, Masahiro Wakao, Hiroshi Deguchi, 2010

机译：朝向肝素和硫酸普乙肝素寡糖文库的组装：有效合成尿酸和二糖构造块

Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate

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