Cinchonidine thiourea catalyzed asymmetric addition of phenols to oxindole derivatives

Kaur Jasneet; Kumar Akshay; Chimni Swapandeep Singh

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Cinchonidine thiourea catalyzed asymmetric addition of phenols to oxindole derivatives

机译：辛可尼定硫脲催化苯酚不对称加成到羟吲哚衍生物上

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A highly enantioselective Friedel-Crafts reaction of activated phenols with isatin derivatives has been developed employing Cinchona-derived thiourea as an organocatalyst. A variety of biologically important 3-aryl-3-hydroxy-2-oxindoles have been synthesized using phenols in good to excellent yield with good enantioselectivity (up to 92% ee).

机译：使用金鸡纳衍生的硫脲作为有机催化剂，已经开发出了一种高度对映选择性的活化酚与靛红衍生物的弗瑞德-克来福特反应。使用苯酚已经合成了多种具有重要生物学意义的3-芳基-3-羟基-2-氧吲哚，并具有良好的对等收率（对映体选择性高达92％ee）。

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《RSC Advances》 |2014年第107期|共8页
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Kaur Jasneet; Kumar Akshay; Chimni Swapandeep Singh;
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1. Cinchonidine thiourea catalyzed asymmetric addition of phenols to oxindole derivatives [J] . Kaur Jasneet, Kumar Akshay, Chimni Swapandeep Singh RSC Advances . 2014,第107期

机译：辛可尼定硫脲催化苯酚不对称加成到羟吲哚衍生物上
2. Asymmetric Michael Addition Reaction of 3-Substituted Oxindoles to Nitroolefins Catalyzed by a Chiral Alkyl-Substituted Thiourea Catalyst [J] . Xin Li, Bo Zhang, Zhi-Guo Xi Advanced synthesis & catalysis . 2010,第2a3期

机译：手性烷基取代的硫脲催化剂催化3-取代的吲哚与硝基烯烃的不对称迈克尔加成反应
3. Asymmetric Michael addition reaction of 3-substituted-N-Boc oxindoles to activated terminal alkenes catalyzed by a bifunctional tertiary-amine thiourea catalyst [J] . Xin Li, Zhi-Guo Xi, Sanzhong Luo, Organic & biomolecular chemistry . 2010,第1期

机译：双官能叔胺硫脲催化剂催化3-取代-N-Boc羟吲哚与活化的末端烯烃的不对称迈克尔加成反应
4. Asymmetric O-Allylation of Phenol Derivatives Catalyzed by Planar-Chiral Cyclopentadienyl-Ruthenium Complexes [C] . Haruki Okuda, Kiyotaka Onitsuka, Hiroaki Sasai Symposium on Organometallic Chemistry . 2006

机译：平面 - 手性环戊二烯基 - 钌配合物催化的苯酚衍生物的不对称O-烯丙基
5. Part I: Vanadium-Catalyzed Asymmetric Oxidative Coupling of Phenols and Hydroxycarbazoles and Its Mechanistic Study. Part II: Total Synthesis of Chaetoglobin A. Part III: Ligand Evolution to Drive Reaction Discovery. Part IV: Oxidative Coupling of 3-Oxindoles to Construct Quaternary Centers [D] . Kang, Houng 2018

机译：第一部分：钒催化苯酚和羟基咔唑的不对称氧化偶合及其机理研究。第二部分：脂球蛋白A的全合成。第三部分：配体进化以驱动反应发现。第四部分：3-氧辛二烯的氧化偶联以构建四元中心
6. Asymmetric Michael addition reactions catalyzed by calix4thiourea cyclohexanediamine derivatives [O] . Zheng-Yi Li, Hong-Xiao Tong, Yuan Chen, 2018

机译：杯4硫脲环己二胺衍生物催化的不对称迈克尔加成反应
7. Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-Tertiary Amine [O] . Liao Yu-Hua, Liu Xiong-Li, Wu Zhi-Jun, 2010

机译：手性双官能硫脲-叔胺催化3-取代的吲哚向马来酰亚胺的高度非对映和对映选择性迈克尔加成反应

Cinchonidine thiourea catalyzed asymmetric addition of phenols to oxindole derivatives

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