首页> 外文期刊>RSC Advances >Identification of MRC2 and CD209 receptors as targets for photodynamic therapy of retinoblastoma using mesoporous silica nanoparticles
【24h】

Identification of MRC2 and CD209 receptors as targets for photodynamic therapy of retinoblastoma using mesoporous silica nanoparticles

机译:使用中孔二氧化硅纳米粒子鉴定MRC2和CD209受体作为视网膜母细胞瘤光动力治疗的靶标

获取原文
获取原文并翻译 | 示例
           

摘要

Research in nanomedicine has grown rapidly over the past few years and is playing a key role in the development of effective treatments for ophthalmological purpose. Retinoblastoma is an intraocular tumor triggered by genetic mutation in young children and photodynamic therapy (PDT) is currently developed as a promising non-mutagenic approach to treat this cancer. In this work, we have first identified two receptors, MRC2 and CD209, which are highly expressed by retinoblastoma. Then, we developed mesoporous silica nanoparticles (MSN) grafted with the antibodies anti-MRC2 and/or anti-CD209 for retinoblastoma PDT and imaging.
机译:在过去的几年中,纳米医学的研究发展迅速,并且在开发眼科有效治疗方法中发挥着关键作用。视网膜母细胞瘤是一种由幼儿中的基因突变触发的眼内肿瘤,目前,光动力疗法(PDT)已被开发为一种有前途的非诱变方法来治疗这种癌症。在这项工作中,我们首先确定了两个受体,MRC2和CD209,它们由成视网膜细胞瘤高度表达。然后,我们开发了移植有抗MRC2和/或抗CD209抗体的介孔二氧化硅纳米粒子(MSN),用于视网膜母细胞瘤PDT和成像。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号