Indium-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones

Jamal Zaini; Teo Yong-Chua

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Indium-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones

机译：铟催化的C（sp（3））-H的2-甲基氮杂芳烃通过直接苄基加成到三氟甲基酮的功能化

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The application of trivalent indium for the Lewis acid-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes is reported. InCl3 was discovered to catalyze the direct addition of the benzylic C-H bond in the azaarenes to trifluoromethyl ketones. An ample number of substrates were cogently demonstrated to give the products as tri-fluoromethylated alcohols whereby in some cases, up to quantitative yield (99%) could be obtained.

机译：报道了三价铟在路易斯酸催化的2-甲基氮杂芳烃的C（sp（3））-H官能化中的应用。发现InCl 3催化氮杂芳烃中苄基C-H键直接加成到三氟甲基酮上。令人信服地证明了足够数量的底物使产物为三氟甲基化醇，因此在某些情况下，可以获得高达定量的收率（99％）。

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《RSC Advances》 |2015年第34期|共5页
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Jamal Zaini; Teo Yong-Chua;
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正文语种 eng
中图分类化学;
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1. Indium-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones [J] . Jamal Zaini, Teo Yong-Chua RSC Advances . 2015,第34期

机译：铟催化的C（sp（3））-H的2-甲基氮杂芳烃通过直接苄基加成到三氟甲基酮的功能化
2. BENZYLIC SP3 C-H FUNCTIONALIZATION REACTION OF 2-METHYLAZAARENES CATALYZED BY PEPSIN [J] . Ai Feng, Chen Guo-Qing, Ji Jiu-Jian, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2018,第8期

机译：胃蛋白酶催化的2-甲基丙酮的苄基SP3 C-H官能化反应
3. Direct C(sp(3))-H functionalization of 2-methylazaarenes using 4-substituted-TEMPO [J] . Zhu Chuanlei, Li Hongming, Chu Changhu Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2018,第51期

机译：直接C（SP（3）） - 使用4替换 - 速度的2-甲基氧化物的H官能化
4. A Green Procedure for the Ionic Liquid Catalyzed Oxidation of Benzylic Alcohols to Aldehydes or Ketones in Aqueous Media [C] . Guo-feng Zhang, Xiu-jie Ji, Bo-wen Cheng China National Conference on Functional Materials and Applications . 2014

机译：在含水介质中催化离子液体催化苄醇或酮的绿色程序
5. Catalytic Enantioselective Additions of Allyl Moieties to α-Halomethyl Ketones, Trifluoromethyl Substituted Nh-Ketimines, and Nitriles [D] . Fager, Diana C. 2020

机译：烯丙基部分催化对α-卤代甲基酮，三氟甲基取代的NH-酮酰亚胺和腈
6. An atom-economical addition of methyl azaarenes with aromatic aldehydes via benzylic C(sp3)–H bond functionalization under solvent- and catalyst-free conditions [O] . Divya Rohini Yennamaneni, Vasu Amrutham, Krishna Sai Gajula, 2020

机译：通过苄基C（SP3）-H键官能化在溶剂和催化剂条件下与芳香族醛进行原子经济的加入甲基α1azaarenes
7. An atom-economical addition of methyl azaarenes with aromatic aldehydes via benzylic C(sp3)–H bond functionalization under solvent- and catalyst-free conditions [O] . Divya Rohini Yennamaneni, Vasu Amrutham, Krishna Sai Gajula, 2020

机译：通过苄基C（SP3）-H键官能化在溶剂和催化剂条件下与芳香族醛进行原子经济的加入甲基α1azaarenes

Indium-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones

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