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Multi-omics based changes in response to cadmium toxicity in Bacillus licheniformis A

机译：基于多组学的地衣芽孢杆菌A对镉毒性的响应变化

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摘要

Cadmium (Cd), a widespread substance with high toxicity and persistence, is known to cause a broad range of adverse effects in all living organisms. However, many microorganisms have special detoxification mechanisms for Cd. In this study, we investigated the response to Cd in Bacillus licheniformis A at the omics level. Proteomic biomarkers were identified, including peroxiredoxin, nucleoside diphosphate kinase, trigger factor, and elongation factor Tu. These proteins suggested that Cd could induce oxidative stress, disturbance in energy metabolism, and protein synthesis in B. licheniformis A. Furthermore, metabolites (glutamate, glycine, and S-adenosylhomocysteine) involved in the glutathione synthesis pathway were also affected. In addition, some metabolic biomarkers were validated by relating to respective proteins, including 50S ribosomal protein L7/L12, trigger factor, peroxiredoxin and superoxide dismutase in B. licheniformis A. This study provides new insights into the utilization of an omics approach in bacteria to assess the effects of Cd pollution in the environment.
机译：镉（Cd）是一种具有高毒性和持久性的普遍物质，已知会在所有活生物体中引起广泛的不良影响。但是，许多微生物对Cd具有特殊的解毒机理。在这项研究中，我们在组学水平上调查了地衣芽孢杆菌A对Cd的反应。鉴定了蛋白质组生物标志物，包括过氧化物酶，核苷二磷酸激酶，触发因子和延伸因子Tu。这些蛋白质表明Cd可以诱导地衣芽孢杆菌A中的氧化应激，能量代谢紊乱和蛋白质合成。此外，谷胱甘肽合成途径中涉及的代谢产物（谷氨酸，甘氨酸和S-腺苷同型半胱氨酸）也受到影响。此外，通过与地衣芽孢杆菌A中的50S核糖体蛋白L7 / L12，触发因子，过氧化物酶和超氧化物歧化酶相关的蛋白质相关联，对一些代谢生物标记物进行了验证。这项研究为利用细菌学组学方法对细菌进行了新的见解。评估镉污染对环境的影响。

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