• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications
【24h】

Novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

机译：通过相分离制备的新型可生物降解的聚富马​​酸丙二醇酯-共聚-L-乳酸多孔支架，用于组织工程应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Scaffolds with intrinsically interconnected porous structures are highly desirable in tissue engineering and regenerative medicine. In this study, three-dimensional polymer scaffolds with highly interconnected porous structures were fabricated by thermally induced phase separation of novel synthesized biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) in a dioxane/water binary system. Defined porous scaffolds were achieved by optimizing conditions to attain interconnected porous structures. The effect of phase separation parameters on scaffold morphology were investigated, including polymer concentration (1, 3, 5, 7, and 9%), quench time (1, 4, and 8 min), dioxane/water ratio (83/17, 85/15, and 87/13 wt/wt), and freeze temperature (-20, -80, and -196 degrees C). Interesting pore morphologies were created by adjusting these processing parameters, e.g., flower-shaped (5%; 85/15; 1 min; -80 degrees C), spherulite-like (5%; 85/15; 8 min; -80 degrees C), and bead-like (5%; 87/13; 1 min; -80 degrees C) morphology. Modulation of phase separation conditions also resulted in remarkable differences in scaffold porosities (81-91%) and thermal properties. Furthermore, scaffolds with varied mechanic strengths, degradation rates, and protein adsorption capabilities could be fabricated using the phase separation method. In summary, this work provides an effective route to generate multi-dimensional porous scaffolds that can be applied to a variety of hydrophobic polymers and copolymers. The generated scaffolds could potentially be useful for various tissue engineering applications including bone tissue engineering.
机译：具有内在互连的多孔结构的支架在组织工程和再生医学中是非常需要的。在这项研究中，通过在二恶烷/水二元体系中热诱导相合成新型合成的可生物降解的聚富马​​酸丙二醇酯-共聚L-乳酸，来制造具有高度互连的多孔结构的三维聚合物支架。通过优化条件以获得相互连接的多孔结构，可以实现确定的多孔支架。研究了相分离参数对支架形态的影响，包括聚合物浓度（1、3、5、7和9％），淬灭时间（1、4和8分钟），二恶烷/水比（83/17， 85/15和87/13 wt / wt）和冷冻温度（-20，-80和-196摄氏度）。通过调整这些加工参数可以创建有趣的孔形态，例如花形（5％; 85/15; 1分钟; -80摄氏度）;类球晶（5％; 85/15; 8分钟; -80摄氏度） C）和珠状（5％; 87/13; 1分钟; -80摄氏度）形态。相分离条件的调节还导致支架孔隙率（81-91％）和热性能的显着差异。此外，可以使用相分离方法制造具有不同机械强度，降解速率和蛋白质吸附能力的支架。总而言之，这项工作为生成可应用于多种疏水性聚合物和共聚物的多维多孔支架提供了一条有效途径。产生的支架可能可用于包括骨组织工程在内的各种组织工程应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号