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Biologic treatments for adult-onset still's disease

机译:成年静止性疾病的生物治疗

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Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder that is a diagnosis of exclusion. It is characterized by high spiking fevers, arthritis or arthralgia, and an evanescent salmon-coloured rash. Many other systemic manifestations and laboratory test abnormalities may occur. Biologic drugs, TNF-α inhibitors, and IL-1 and IL-6 blockers have been used for the treatment of patients with AOSD refractory to conventional treatment or those with life-threatening manifestations aiming for better disease control. Data on biologic treatments in AOSD are limited and consist mainly of case reports, small case series and retrospective studies. Using biologic agents (anti-TNF-α, anti-IL-1 and anti-IL-6) with traditional immunosuppressive drugs resulted in significant improvement of disease outcomes. IL-1 and IL-6 inhibitors seem to be more efficient than TNF-α inhibitors.
机译:成人发作性斯蒂尔氏病(AOSD)是一种全身性炎症,被诊断为排斥反应。它的特征是发高烧,关节炎或关节痛,以及淡淡的鲑鱼色皮疹。可能还会发生许多其他全身表现和实验室检查异常。生物药物,TNF-α抑制剂以及IL-1和IL-6阻滞剂已用于治疗常规治疗难以治愈的AOSD或具有威胁生命生命表现的患者,旨在更好地控制疾病。 AOSD中生物治疗的数据有限,主要包括病例报告,小病例系列研究和回顾性研究。与传统的免疫抑制药物一起使用生物制剂(抗TNF-α,抗IL-1和抗IL-6)可显着改善疾病结局。 IL-1和IL-6抑制剂似乎比TNF-α抑制剂更有效。

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