...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological trace element research >Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken
【24h】

Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken

机译：日粮硒抗铅毒性对肉仔鸡软骨组织中25种硒蛋白基因mRNA水平的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The interactions between the essential element selenium (Se) and the toxic element lead (Pb) have been reported extensively; however, little is known about the effect of Se on Pb toxicity and the expression pattern of selenoproteins in the cartilage of chicken. To investigate the effects of Se on Pb toxicity and the messenger RNA (mRNA) expressions of selenoproteins in cartilage tissue, an in vitro study was performed on 1-day-old broiler chickens (randomly allocated into four groups) with diet of different concentration of Se and Pb. After 90 days, the meniscus cartilage and sword cartilage tissue were examined for the mRNA levels of 25 selenoprotein genes. The results showed that Se and Pb influenced the expression of selenoprotein genes in the chicken cartilage tissue. In detail, Se could alleviate the downtrend of the expression of Gpx1, Gpx2, Gpx4, Txnrd2, Txnrd3, Dio1, Dio2, Seli, Selu, Sepx1, Selk, Selw, Selo, Selm, Sep15, Sepnn1, Sels, and Selt induced by Pb exposure in the meniscus cartilage. In the sword cartilage, Se alleviated the downtrend of the expression of Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Dio2, Dio3, Seli, Selh, SPS2, Sepx1, Selk, Selw, Selo, Selm, Sep15, Selpb, Sepn1, and Selt induced by Pb exposure. The present study provided some compensated data about the roles of Se against Pb toxicity in the regulation of selenoprotein expression.
机译：必需元素硒（Se）和有毒元素铅（Pb）之间的相互作用已有大量报道。然而，关于硒对Pb毒性的影响以及鸡软骨中硒蛋白的表达模式知之甚少。为了研究硒对软骨组织中硒的铅毒性和硒蛋白的信使RNA（mRNA）表达的影响，对日粮不同浓度的1日龄肉鸡（随机分为四组）进行了体外研究。硒和铅。 90天后，检查半月板软骨和剑软骨组织中25种硒蛋白基因的mRNA水平。结果表明，硒和铅影响了鸡软骨组织中硒蛋白基因的表达。详细地讲，Se可以缓解Gpx1，Gpx2，Gpx4，Txnrd2，Txnrd3，Dio1，Dio2，Seli，Selu，Sep1，Selk，Selw，Selo，Selm，Sel15，Sep15，Sepnn1，Sels和Selt引起的表达下降趋势。半月板软骨中的Pb暴露。在剑软骨中，Se减轻了Gpx2，Gpx3，Gpx4，Txnrd1，Txnrd2，Dio2，Dio3，Seli，Selh，SPS2，Sepx1，Selk，Selw，Selo，Selm，Sep15，Selpb，Sepn1和铅暴露引起的渗出。本研究提供了有关硒抗铅毒性在硒蛋白表达调控中的一些补偿性数据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号