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Emulsion-templated poly(acrylamide)s by using polyvinyl alcohol (PVA) stabilized CO2-in-water emulsions and their applications in tissue engineering scaffolds

机译:使用聚乙烯醇(PVA)稳定的水包CO2乳液的乳液模板聚丙烯酰胺及其在组织工程支架中的应用

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摘要

The key challenge in the formation of stable CO2-in-water (C/W) emulsions has always been the availability of effective surfactants. Most of the surfactants being used for this purpose are expensive and difficult to synthesize, rendering the formation of C/W emulsions an uneconomical and unfavorable process. In this work, we report the use of commercial polyvinyl alcohol as an effective stabilizer for the formation of C/W emulsions at low temperatures. Porous emulsion-templated materials were prepared by the polymerization of the continuous phase of C/W emulsions. The open-cell morphology of the emulsion-templated materials was observed by scanning electron microscopy. To tune the morphology of the porous structures, the influence of the stabilizer concentration and the process of polymerization were investigated. These porous PAM materials were further evaluated for cellular growth and proliferation to demonstrate their applications in tissue engineering.
机译:形成稳定的水包CO2(C / W)乳液的关键挑战一直是有效表面活性剂的可用性。用于该目的的大多数表面活性剂是昂贵的且难以合成,使得C / W乳液的形成是不经济且不利的方法。在这项工作中,我们报告了使用商用聚乙烯醇作为在低温下形成C / W乳液的有效稳定剂。通过C / W乳液连续相的聚合制备多孔乳液模板材料。通过扫描电子显微镜观察乳液模板材料的开孔形态。为了调节多孔结构的形态,研究了稳定剂浓度和聚合过程的影响。进一步评估了这些多孔PAM材料的细胞生长和增殖能力,以证明其在组织工程中的应用。

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