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首页> 外文期刊>RSC Advances >Biochemical and histological changes in the liver and gills of Nile tilapia Oreochromis niloticus exposed to Red 195 dye
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Biochemical and histological changes in the liver and gills of Nile tilapia Oreochromis niloticus exposed to Red 195 dye

机译：暴露于Red 195染料的尼罗罗非鱼Oreochromis niloticus肝脏和g的生化和组织学变化

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摘要

The present study investigates the biochemical and morphological responses induced in the liver and gills of Nile tilapia Oreochromis niloticus by exposure to various Red 195 dye concentrations (0.05, 0.1 and 0.2 mg L-1) for various durations (7, 14 and 21 days). The histology and antioxidant activities of catalase (CAT), glutathione reductase (GR) and glutathione S-transferase (GST) were monitored and evaluated during exposure and after recovery in clean water. The results revealed that CAT activity decreased after 7 and 21 days of exposure to 0.2 mg L-1 concentrations and increased only after 7 days of exposure to high concentrations compared to the liver and gill control samples, respectively. Both organs were, however, noted to undergo a decrease in GST activity after 7 days of exposure to low Red 195 dye concentrations. Compared to the control, the gills of the tilapia exposed to 0.05 and 0.1 mg L-1 concentrations for longer periods underwent an increase in GST activity. Similarly, GR activity was higher in the liver of tilapia exposed to this dye at the sampling days, except for the highest concentration (0.2 mg L-1) after 21 days of exposure. The GR activity in the gills decreased significantly after 7 and 21 days of exposure to 0.05 and 0.1 mg L-1 concentrations, respectively. The results of the recovery group revealed that the liver and gills displayed insignificant differences in antioxidant enzyme activities. The liver and gill tissues of the fish exposed to Red 195 showed several histopathological changes. Liver damages included an increase in cytoplasmic vacuolization, disruption of endothelial lining, metabolic zonation, necrotic cells, rupture of hepatocyte membrane, and decline of higher eosinophilia. The gills also exhibited some necrotic cells, edema, lifting of filaments and lamellar epithelium, and vascular disorders, such as extreme vasodilatation and proliferation of filament epithelium. A correlation between the biochemical and histological changes of the liver and gill tissues was established, attributing the tissue and cell damages to the accumulation of hydrogen peroxide or production of other radicals via a Fenton reaction.
机译：本研究调查了尼罗罗非鱼Oreochromis niloticus的肝脏和g中通过暴露于各种Red 195浓度（0.05、0.1和0.2 mg L-1）的持续时间（7、14和21天）诱导的生化和形态反应。在暴露期间以及在干净水中恢复后，对过氧化氢酶（CAT），谷胱甘肽还原酶（GR）和谷胱甘肽S-转移酶（GST）的组织学和抗氧化活性进行了监测和评估。结果表明，与肝脏和腮对照样品相比，CAT活性分别在暴露于0.2 mg L-1浓度7天和21天后降低，仅在暴露于高浓度7天后才增加。但是，在暴露于低浓度Red 195染料7天后，两个器官的GST活性均下降。与对照组相比，长时间暴露于0.05和0.1 mg L-1浓度的罗非鱼the的GST活性增加。同样，在采样日暴露于这种染料的罗非鱼肝中，GR活性较高，但暴露21天后的最高浓度（0.2 mg L-1）除外。暴露于0.05和0.1 mg L-1浓度的7天和21天后，ill的GR活性显着下降。恢复组的结果表明，肝脏和g在抗氧化酶活性方面没有明显差异。暴露于Red 195的鱼的肝脏和g组织显示出几种组织病理学变化。肝损害包括细胞质空泡增加，内皮细胞壁破坏，代谢区带，坏死细胞，肝细胞膜破裂和嗜酸性粒细胞增多。还表现出一些坏死细胞，水肿，细丝和层状上皮提起，以及血管疾病，例如极端的血管扩张和细丝上皮的增殖。建立了肝脏和腮组织的生化和组织学变化之间的相关性，将组织和细胞损伤归因于过氧化氢的积累或通过Fenton反应产生的其他自由基。

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