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首页> 外文期刊>Rheumatology >Pregnancy outcomes in women with juvenile idiopathic arthritis: A population-based study
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Pregnancy outcomes in women with juvenile idiopathic arthritis: A population-based study

机译：少年特发性关节炎妇女的妊娠结局：一项基于人群的研究

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Objective: The aim of this study is to describe pregnancy outcomes among women with JIA. Methods: Women who gave birth in New South Wales (NSW), Australia, were linked to hospital discharge records from 2000 to 2010. Women with an ICD-10-AM code of M08 or M09 in the hospital records were considered to have JIA. Logistic regression was used to calculate odds ratios for pregnancy outcomes and the lack of independence in study outcomes for multiple pregnancies in the same woman was taken into account using generalized estimating equations. Results: During the study period, 601 659 women had 941 496 births. Of these births, 78 births could be attributed to 50 women with JIA. Of 78 JIA pregnancies, 53 (68%) were delivered by either Caesarean section (n = 40, 51%) or instrumental delivery (n = 13, 17%); compared with other women, those with JIA had significantly higher rates of pre-eclampsia, postpartum haemorrhage and severe maternal morbidity. Compared with other infants, those with mothers with JIA were more likely to be born prematurely, but were not at increased risk of being small for gestational age, requiring neonatal intensive care, having a low Apgar score at 5 min or severe neonatal morbidity. Conclusion Infants of women with JIA did not have an increased risk of adverse neonatal outcomes. Intensive obstetric care might be required during pregnancy for women with JIA given the increased risk of maternal morbidity.
机译：目的：本研究的目的是描述JIA妇女的妊娠结局。方法：将2000年至2010年在澳大利亚新南威尔士州（NSW）分娩的妇女与出院记录相关联。医院记录中ICD-10-AM码为M08或M09的妇女被视为患有JIA。使用Logistic回归来计算妊娠结局的比值比，并使用广义估计方程来考虑同一位妇女多次妊娠的研究结局缺乏独立性。结果：在研究期间，601659名妇女生育了941496例婴儿。在这些分娩中，有78例分娩可以归因于50名JIA妇女。在78例JIA怀孕中，有53例（68％）通过剖腹产（n = 40、51％）或通过工具分娩（n = 13、17％）分娩;与其他女性相比，患有JIA的女性先兆子痫，产后出血和严重的母亲发病率更高。与其他婴儿相比，患有JIA的母亲早产的可能性更高，但胎龄较小的风险并未增加，因此需要新生儿重症监护，5分钟Apgar评分低或严重的新生儿发病率。结论患有JIA的女性婴儿的新生儿不良结局风险没有增加。鉴于孕产妇发病风险增加，JIA妇女在怀孕期间可能需要重症监护。

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