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Systematic review of association between vitamin D levels and susceptibility and disease activity of ankylosing spondylitis

机译：系统评价维生素D水平与强直性脊柱炎的易感性和疾病活性之间的关联

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Objectives: Vitamin D appears to have significant effects on both innate and acquired immunity and deficiency may be associated with both susceptibility and disease severity in some autoimmune conditions. There has been little focus on the potential immunomodulatory role of vitamin D in AS. This study systematically reviews the evidence for an association between vitamin D deficiency and disease susceptibility and severity in AS. Methods: A systematic review was conducted using Medline, EMBASE, Web of Science and conference abstracts of the European League Against Rheumatism (2002-13), British Society for Rheumatology (1993-2013) and ACR (2006-13). Results: Fifteen original articles and five conference abstracts met the criteria for inclusion. All were crosssectional in design. Seven of 11 studies identified lower concentrations of 25-hydroxyvitamin D (25OHD) in AS patients compared with healthy controls. A significant inverse correlation between 25OHD and disease activity was observed in 5 of 11 studies. The majority of studies that failed to demonstrate significant findings used inappropriate statistical methods. Conclusion: Cross-sectional studies using appropriate statistical analyses have highlighted that AS is associated with lower vitamin D concentrations. Within groups of AS patients there is some evidence that low vitamin D concentrations are associated with higher disease activity. However, there are insufficient published data to support an immunomodulatory role for vitamin D in AS. Further study with a longitudinal design is required to understand whether optimizing vitamin D in AS has potential as a disease-modifying intervention.
机译：目的：维生素D似乎对先天和后天免疫均具有显著作用，在某些自身免疫性疾病中，维生素D缺乏可能与易感性和疾病严重程度有关。很少有人关注维生素D在AS中的潜在免疫调节作用。这项研究系统地回顾了维生素D缺乏与AS中疾病易感性和严重性之间相关性的证据。方法：使用Medline，EMBASE，Web of Science和欧洲抗风湿病联盟（2002-13），英国风湿病学会（1993-2013）和ACR（2006-13）的会议摘要进行了系统的综述。结果：15篇原创文章和5篇会议摘要符合纳入标准。所有的设计都是横截面的。 11项研究中的7项确定AS患者的25-羟基维生素D（25OHD）浓度低于健康对照组。在11项研究中的5项中，观察到25OHD与疾病活动之间显着的负相关。大多数未能证明重要发现的研究使用了不适当的统计方法。结论：使用适当的统计分析进行的横断面研究强调，AS与较低的维生素D浓度有关。在AS患者组中，有一些证据表明低维生素D浓度与较高的疾病活动性有关。但是，尚无足够的公开数据支持维生素D在AS中的免疫调节作用。需要进行纵向设计的进一步研究，以了解在AS中优化维生素D是否具有潜在的缓解疾病的干预作用。

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