• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Interaction of bio-relevant thio-ether and thiols with dinuclear Pd(II) complex: kinetics, mechanism, bioactivity in aqueous medium and molecular docking
【24h】

Interaction of bio-relevant thio-ether and thiols with dinuclear Pd(II) complex: kinetics, mechanism, bioactivity in aqueous medium and molecular docking

机译：生物相关的硫醚和硫醇与双核Pd（II）配合物的相互作用：动力学，机理，在水性介质中的生物活性和分子对接

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The kinetics of interaction between [Pd(pic)(OH)](2)(ClO4)(2), 2 (pic = 2-aminomethylpyridine) with the selected ligands (L) DL-methionine (DL-meth), L-cysteine (L-cys) and N-acetyl-L-cysteine (N-ac-L-cys) have been studied under pseudo-first order conditions using a stopped-flow spectrophotometer in aqueous medium as a function of [complex 2] as well as [ligand], pH, and temperature at constant ionic strength. The ligand dependent second order reaction is found to take place in two consecutive steps in accordance with the rate law, k((obs)) = k(1)[L](2) in which all these three reactions follow the third order kinetics. The first step of the reaction is dependent, while the second step is independent of [ligand] in all the cases. The activation parameters, Delta H-double dagger and Delta S-double dagger for the two-step reactions are evaluated from the Eyring equation. An associative mode of activation (an associative mechanism) in the transition state is proposed for all these substitution processes. Complex 2 and its substituted products [Pd(pic) DL-meth](+) 3; [Pd(pic) L-cys] 4; and [Pd(pic) N-ac-L-cys] 5 are characterized by UV-Vis, FT-IR, 1H-NMR and ESI-mass spectroscopic methods. Complex 2-5 show remarkable anticancer properties on HeLa cells of about 70% at high concentration when compared to cis-platin and antibacterial properties on both the Gram positive (Bacillus subtilis) and Gram negative (E. coli Dh5 alpha) bacteria. In addition, DNA interaction with plasmid DNA is observed and computational molecular docking studies were carried out with an aim to establish the binding mode of complex 2 with B-DNA.
机译：[Pd（pic）（OH）]（2）（ClO4）（2），2（pic = 2-氨基甲基吡啶）与所选配体之间的相互作用动力学（L）DL-蛋氨酸（DL-meth），L-半胱氨酸（L-cys）和N-乙酰基-L-半胱氨酸（N-ac-L-cys）已在拟一级反应条件下使用停流分光光度计在水性介质中作为[复合物2]的函数进行了研究。以及在恒定离子强度下的[配体]，pH和温度。发现根据速率定律k（（obs））= k（1）[L]（2），配体依赖性二阶反应在两个连续的步骤中发生，其中所有这三个反应均遵循三阶动力学。在所有情况下，反应的第一步是独立的，而第二步是独立于配体的。两步反应的活化参数Delta H-double dagger和Delta S-double dagger从Eyring方程计算得出。针对所有这些取代过程，提出了过渡状态下的激活关联模式（关联机制）。配合物2及其取代的产物[Pd（pic）DL-meth]（+）3; [Pd（pic）L-cys] 4;和[Pd（pic）N-ac-L-cys] 5用UV-Vis，FT-IR，1H-NMR和ESI-质谱法表征。与顺铂相比，复合物2-5在高浓度下对HeLa细胞表现出显着的抗癌特性，约70％，对革兰氏阳性（枯草芽孢杆菌）和革兰氏阴性（大肠杆菌Dh5α）细菌均具有抗菌性能。另外，观察到DNA与质粒DNA的相互作用，并进行了计算分子对接研究，目的是建立复合物2与B-DNA的结合方式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号