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首页> 外文期刊>RSC Advances >Tough biodegradable chitosan-gelatin hydrogels via in situ precipitation for potential cartilage tissue engineering
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Tough biodegradable chitosan-gelatin hydrogels via in situ precipitation for potential cartilage tissue engineering

机译：可通过原位沉淀制备坚韧的可生物降解的壳聚糖-明胶水凝胶，用于潜在的软骨组织工程

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摘要

Tough porous chitosan-gelatin (CG) hydrogels have been prepared through in situ precipitation with tunable porosity and degradation rates by adjusting the preparation formulations. Compression tests showed a Young's modulus of 3.25 MPa and a compressive strength of 2.15 MPa for the optimized C4G4 hydrogels, which are similar to or higher than those for human cartilage. Cyclic compression tests showed overlapping hysteresis loops for several cycles, with a compressive toughness of about 75.8 J m(-2). In vitro enzymatic degradation results showed a degradation of 65.9% in 70 days, comparable to the regeneration rate of engineered cartilage reported in literature. Moreover, in vitro cell culture experiments showed excellent adhesion and proliferation of human thyroid cartilage cells on these hydrogels, where the chondrocytes function to secrete ECM. These tough and biodegradable hydrogels may have potential applications for cartilage tissue engineering.
机译：硬质多孔壳聚糖-明胶（CG）水凝胶是通过原位沉淀制备的，可通过调节制剂配方，以可调的孔隙率和降解速率进行制备。压缩测试显示，优化的C4G4水凝胶的杨氏模量为3.25 MPa，抗压强度为2.15 MPa，与人体软骨相似或更高。循环压缩测试显示了几个循环重叠的磁滞回线，其压缩韧性约为75.8 J m（-2）。体外酶促降解结果显示70天内降解了65.9％，与文献报道的工程软骨的再生率相当。此外，体外细胞培养实验表明，人甲状腺软骨细胞在这些水凝胶上具有优异的粘附和增殖能力，其中软骨细胞起着分泌ECM的作用。这些坚韧且可生物降解的水凝胶可能在软骨组织工程中具有潜在的应用。

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