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Phenothiazine based sensor for naked-eye detection and bioimaging of Hg(II) and F- ions

机译:基于吩噻嗪的传感器,用于肉眼检测以及Hg(II)和F-离子的生物成像

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摘要

The design and development of new phenothiazine-based fluorescent probes, which display a selective fluorescence response to mercury and fluoride ions, were described. The probe is the first example that facilitates the detection of Hg2+ at nanomolar concentrations. The sensitivity of probe P-1 to Hg2+ and F- was demonstrated in living cells, and cell toxicity assays revealed that probe P-1 can be used for selective imaging of Hg2+ and F- in living cells. Moreover, the simple probe design presented here may contribute to the development of more efficient and more useful dual-mode probes.
机译:描述了基于吩噻嗪的新型荧光探针的设计和开发,该探针显示出对汞和氟离子的选择性荧光响应。该探针是第一个有助于在纳摩尔浓度下检测Hg2 +的实例。在活细胞中证明了探针P-1对Hg2 +和F-的敏感​​性,并且细胞毒性试验表明,探针P-1可用于活细胞中Hg2 +和F-的选择性成像。此外,此处介绍的简单探头设计可能有助于开发更高效,更有用的双模探头。

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