• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Oxidovanadium(V) complexes of aroylhydrazones incorporating heterocycles: synthesis, characterization and study of DNA binding, photoinduced DNA cleavage and cytotoxic activities
【24h】

Oxidovanadium(V) complexes of aroylhydrazones incorporating heterocycles: synthesis, characterization and study of DNA binding, photoinduced DNA cleavage and cytotoxic activities

机译：含杂环的芳酰hydr的氧化钒（V）配合物：DNA结合，光致DNA裂解和细胞毒性活性的合成，表征和研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Four neutral oxidovanadium(V) complexes VO2L1 (1), VO2L2 (2), VOL3(OEt) (3) and VOL4(OEt)EtOH (4) [where HL1 = 2-thiophenoylhydrazone of 2-acetylpyridine, HL2 = 2-amino benzoylhydrazone of 2-benzoyl pyridine, H2L3 = isonicotinoylhydrazone of 2-hydroxy acetophenone, H2L4 = 2-furoylhydrazone of 2-hydroxy-1-napthaldehyde] with a hydrazone scaffold containing either furan, thiophene and pyridine residues have been synthesised. All complexes were thoroughly characterized by various spectroscopic (IR, UV-Vis, NMR and ESI-MS) and single crystal X-ray diffraction techniques. Crystallography establishes five-coordinate geometries, distorted toward square pyramidal for each of 1 and 2, based on a tridentate-O,N,N coordinating anion and two oxido-O atoms. The dianion in 3 is tetradentate, coordinating one V atom as for 1 and 2, and bridging another via the pyridyl-N atom, and the N2O4 octahedral coordination geometry is completed by oxido- and ethanolate-O atoms. The result of the V-N bridging is a helical coordination polymer. An NO5 octahedral geometry is found in 4 defined by a tridentate-O,N,O anion, as well as oxido-, ethanolate- and ethanol-O atoms. Biological studies reveal that 1-4 have DNA binding propensity and show these to interact with CT-DNA through the minor groove binding mode, with binding constants ranging from 10(3) to 10(5) M-1. All complexes show good photo-induced cleavage of pUC19 supercoiled plasmid DNA with 3 showing the highest photo-induced DNA cleavage activity of similar to 65%. Additionally, 1-4 are cytotoxic against the human cervical cancer cell line (HeLa) with IC50 values ranging from 10 to 20 mu M.
机译：四种中性氧化钒（V）络合物VO2L1（1），VO2L2（2），VOL3（OEt）（3）和VOL4（OEt）EtOH（4）[其中HL1 = 2-乙酰基吡啶的2-噻吩酰hydr，HL2 = 2-氨基合成了带有含呋喃，噻吩和吡啶残基的骨架的2-苯甲酰吡啶的苯甲酰,、 H2L3 = 2-羟基苯乙酮的异烟酰yl，H2L4 = 2-羟基-1-萘乙醛的2-呋喃hydr。所有配合物均通过各种光谱（红外，紫外-可见，NMR和ESI-MS）和单晶X射线衍射技术进行了全面表征。晶体学基于三齿-O，N，N配位阴离子和两个氧-O原子，建立了五坐标的几何形状，对于1和2中的每一个，都向方形锥体变形。 3中的二价阴离子是四齿的，与1和2配位一个V原子，并通过吡啶基-N原子桥连另一个，N2O4八面体的配位几何结构是由氧-和乙醇-O原子完成的。 V-N桥接的结果是螺旋配位聚合物。发现NO5八面体的几何形状由4个三齿-O，N，O阴离子以及氧化，乙醇化和乙醇-O原子定义。生物学研究表明1-4具有DNA结合倾向，并显示它们通过小沟结合模式与CT-DNA相互作用，结合常数范围为10（3）至10（5）M-1。所有复合物均显示出pUC19超螺旋质粒DNA的良好光诱导裂解性，其中3个显示出最高的光诱导DNA裂解活性，接近65％。此外，1-4对人宫颈癌细胞系（HeLa）具有细胞毒性，IC50值介于10至20μM之间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号