Mexicanolide limonoids with in vitro neuroprotective activities from seeds of Khaya senegalensis

Li Hui; Li Yi; Wang Xiao-Bing; Pang Tao; Zhang Lu-Yong; Luo Jun; Kong Ling-Yi

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Mexicanolide limonoids with in vitro neuroprotective activities from seeds of Khaya senegalensis

机译：塞内加尔茄子种子中具有体外神经保护活性的墨西哥菊香柠檬苦素

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Fourteen new mexicanolide-type limonoids, khasenegasins A-N (1-14), together with three known limonoids (15-17) were isolated from the seeds of Khaya senegalensis (Desr.) A. Juss. Their structures were elucidated on the basis of NMR, HRMS and single crystal diffraction techniques. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction using mirror Cu K alpha radiation. Two of the compounds (6 and 17) displayed in vitro neuroprotective activities against glutamate-induced injury in primary rat cerebellar granule neuronal cells (CGCs) at a concentration of 10 mu M and 1 mu M.

机译：从塞内加尔哈萨克（A. Juss。在NMR，HRMS和单晶衍射技术的基础上阐明了它们的结构。化合物1的绝对构型通过使用镜面Cu Kα辐射的单晶X射线衍射测定。两种化合物（6和17）在浓度为10μM和1μM的原代大鼠小脑颗粒神经元细胞（CGC）中显示出针对谷氨酸诱导的损伤的体外神经保护活性。

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《RSC Advances》 |2015年第51期|共10页
作者
Li Hui; Li Yi; Wang Xiao-Bing; Pang Tao; Zhang Lu-Yong; Luo Jun; Kong Ling-Yi;
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正文语种 eng
中图分类化学;
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1. Mexicanolide limonoids with in vitro neuroprotective activities from seeds of Khaya senegalensis [J] . Li Hui, Li Yi, Wang Xiao-Bing, RSC Advances . 2015,第51期

机译：塞内加尔茄子种子中具有体外神经保护活性的墨西哥菊香柠檬苦素
2. In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis. [J] . Fall AB, Vanhaelen Fastre-R, Vanhaelen M, Planta medica: Natural products and medicinal plant research . 1999,第3期

机译：从塞内加尔海藻中分离的重排柠檬苦素的体外抗刺活性。
3. New Structurally Diverse Limonoids from the Seeds of Khaya senegalensis [J] . Tian Xiaomeng, Li Hui, An Faliang, Planta medica: Natural products and medicinal plant research . 2017,第3a4期

机译：来自Khaya Senegalensis种子的新结构多样化的脂蛋白
4. SEM Study of Oil Adsorption on the Surface of Khaya Senegalensis Dried Leaves [C] . Ziyad Said, Habsah Alwi International Conference on Chemical, Biological and Environmental Engineering . 2014

机译：SEM对Khaya Senegalensis干叶表面的油吸附研究
5. Assessing the impact of bark and foliage harvest on Khaya senegalensis (Meliaceae) in Benin, West Africa. [D] . Gaoue, Orou G. 2008

机译：评估树皮和树叶收成对西非贝宁的塞内加尔海藻（M科）的影响。
6. In vitro and in vivo anti-malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production [O] . Tiago B Pereira, Luiz F Rocha e Silva, Rodrigo CN Amorim, 2014

机译：从瓜子锦葵（andiroba）产油中残留种子生物质中分离的柠檬苦素类化合物的体外和体内抗疟活性
7. In vitro Preliminary Study of Free Radical Scavenging Activity of Extracts from Khaya senegalensis A. Juss. (Meliaceae) [O] . Marius Lompo, Jacques Dubois ., I. Pierre Guissou . 2007

机译：Khaya Senegalensis A. Juss Zhays Zhase的自由基清除活性的体外初步研究。（Meliaceae）

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Mexicanolide limonoids with in vitro neuroprotective activities from seeds of Khaya senegalensis

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