Enhancement of the affinity of 2 '-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone

Nukaga Yohei; Takemura Tetsuhiko; Iwamoto Naoki; Oka Natsuhisa; Wada Takeshi

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Enhancement of the affinity of 2 '-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone

机译：通过掺入立体调节的硼磷酸盐骨架，增强2'-O-Me-寡核苷酸对互补RNA的亲和力

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2'-O-Me-oligoribonucleotides bearing a stereoregulated boranophosphate backbone (2'-O-Me-PB-ORNs) were synthesized by using 2'-O-Me-ribonucleoside 3'-O-oxazaphospholidine monomers. A thermal denaturation study of the resultant diastereopure 2'-O-Me-PB-ORNs revealed that an all-(Sp)-boranophosphate backbone had a large stabilizing effect on the duplex with complementary RNA.

机译：通过使用2'-O-Me-核糖核苷3'-O-氧杂氮杂膦酸单体合成具有立体调节的硼酸磷酸骨架的2'-O-Me-寡核糖核苷酸（2'-O-Me-PB-ORNs）。对所得非对映体2'-O-Me-PB-ORN的热变性研究表明，全-（Sp）-硼酸磷酸酯骨架对具有互补RNA的双链体具有较大的稳定作用。

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《RSC Advances》 |2015年第4期|共4页
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Nukaga Yohei; Takemura Tetsuhiko; Iwamoto Naoki; Oka Natsuhisa; Wada Takeshi;
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正文语种 eng
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1. Enhancement of the affinity of 2 '-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone [J] . Nukaga Yohei, Takemura Tetsuhiko, Iwamoto Naoki, RSC Advances . 2015,第4期

机译：通过掺入立体调节的硼磷酸盐骨架，增强2'-O-Me-寡核苷酸对互补RNA的亲和力
2. Tricyclic 2′-Deoxycytidine Analogs: Syntheses and Incorporation into Oligodeoxynucleotides Which Have Enhanced Binding to Complementary RNA [J] . Kuei-Ying Lin, Robert J. Jones, Mark Matteucci Journal of the American Chemical Society . 1995,第13期

机译：三环2'-脱氧胞苷类似物：合成和并入具有增强的互补RNA结合的寡脱氧核苷酸
3. Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex [J] . Egli Martin, Lybrand Terry P. Journal of the American Chemical Society . 2019,第10期

机译：通过二硫代磷酸酯基团合并获得的增强的分散和极化相互作用产生显着的RNA适体-凝血酶复合物的结合亲和力增加。
4. Enhancing motion segmentation by combination of complementary affinities [C] . Zografos, Vasileios ICPR 2012;International Conference on Pattern Recognition . 2012

机译：通过补充亲和力来增强运动分割
5. Will collaboration or affiliation between allopathic medical schools and complementary and alternative medicine (CAM) accredited schools better incorporate CAM into allopathic medical school curriculum? [D] . Horton, Rosanna M. 2009

机译：同种疗法医学院与经补充和替代医学（CAM）认可的学校之间的合作或从属关系是否会更好地将CAM纳入同种疗法医学院的课程中？
6. Origins of the enhanced affinity of RNA-protein interactions triggered by RNA phosphorodithioate backbone modification [O] . Xianbin Yang, N. Dinuka Abeydeera, Feng-Wu Liu, -1

机译：RNA二硫代磷酸酯骨架修饰引发的RNA-蛋白质相互作用亲和力增强的起源
7. Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification [O] . Xianbin Yang, N. Dinuka Abeydeera, Feng-Wu Liu, 2017

机译：RNA-蛋白质相互作用的增强亲和力的起源是由RNA磷偶氮硫代氨酸骨架修饰引发的

Enhancement of the affinity of 2 '-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone

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