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首页> 外文期刊>RSC Advances >Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging
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Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging

机译：基于新型AEE氟的高效近红外有机点用于特定癌细胞成像

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摘要

Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer poly(styrene-co-maleic anhydride) (PSMA) as the co-encapsulation matrix and a novel small molecule fluorogen (DPPBPA) with high near-infrared emission as the core. The PSMA dots show small particle size of about 20 nm, a large Stokes shift of 304 nm and really high fluorescence quantum efficiency of 20%. The streptavidin-dots are obtained by conjugating streptavidin to carboxyl groups on the surface of PSMA dots. These streptavidin-dots can effectively and specifically label the target cell without any nonspecific binding, such as MCF-7 cells. Together with the negligible cytotoxicity, the near-infrared emissive AEE dots are promising red fluorescent probes for future bioimaging applications.
机译：通过使用两亲性聚合物聚苯乙烯-顺丁烯二酸酐（PSMA）作为共包封基质和新型小分子氟（DPPBPA）制备具有高荧光量子效率的近红外发射有机点（AEE点）以高近红外发射为核心。 PSMA点显示出约20 nm的小粒径，304 nm的大斯托克斯位移和20％的高荧光量子效率。链霉亲和素点是通过将链霉亲和素与PSMA点表面的羧基缀合而获得的。这些链霉亲和素点可以有效和特异性地标记靶细胞，而无需任何非特异性结合，例如MCF-7细胞。连同可忽略的细胞毒性，近红外发射AEE点是有希望用于未来生物成像应用的红色荧光探针。

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