• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >PDMS micropillar-based microchip for efficient cancer cell capture
【24h】

PDMS micropillar-based microchip for efficient cancer cell capture

机译：基于PDMS微柱的微芯片可有效捕获癌细胞

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We introduce a micropillar-based microfluidic device for efficient and rapid cancer cell capture. The microfluidic chip consists of two linear arrays of micropillars integrated with a herringbones flow-derived microstructure, and the separation distance between two adjacent micropillars is similar to the size of tumor cells. Cancer cells can be forced to come into contact with the micro-columns and are then captured by specific immune antibody-antigen interactions. Both previously published data and new available experimental data confirm the superiority of the proposed device. Different cancer cell lines were utilized to investigate the capture efficiency of our microfluidic device. MCF-7 cancer cells spiked into DMEM culture medium can be captured from a suspension with over 90% efficiency. The results of the present work provide a promising method for separation of rare cells, such as circulating tumor or fetal cells.
机译：我们介绍了基于微柱的微流控设备，可高效，快速地捕获癌细胞。微流控芯片由两个线性阵列的微柱组成，这些线性柱集成了人字形流动衍生的微结构，两个相邻的微柱之间的分离距离类似于肿瘤细胞的大小。癌细胞可能被迫与微柱接触，然后被特异性免疫抗体-抗原相互作用捕获。先前发布的数据和新的可用实验数据都证实了所提出设备的优越性。利用不同的癌细胞系来研究我们微流控设备的捕获效率。掺入DMEM培养基的MCF-7癌细胞可以从悬浮液中捕获，效率超过90％。本工作的结果为分离稀有细胞，例如循环肿瘤或胎儿细胞提供了一种有前途的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号