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Investigation of dendrimers functionalized with eosin as macrophotoinitiators for polymerization-based signal amplification reactions

机译：曙红官能化的树枝状大分子作为基于聚合反应的信号放大反应的大光引发剂的研究

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摘要

Polymerization-based signal amplification, a technique developed for use in rapid diagnostic tests, hinges on the ability to localize initiators as a function of interfacial binding events. A number of strategies are available for increasing this local concentration, including increasing the capture probe density, using higher affinity binding molecules, or, as presented here, directly conjugating additional initiators to the detection reagent through the use of functionalized polymers. We have previously considered poly(acrylic acid-co-acrylamide) backbones for this purpose; with eosin as the photoinitiator, these efforts were hindered by solubility limitations. Here, we use a poly(amidoamine) dendrimer as a scaffold to produce conjugates with enhanced solubility. Through an investigation into the surface binding and solution-phase properties of these conjugates, we show that quenching effects impact the efficacy of these conjugates as macrophotoinitiators.
机译：基于聚合的信号放大（一种用于快速诊断测试的技术）取决于界面结合事件对引发剂的定位能力。有多种策略可用于提高该局部浓度，包括使用更高的亲和力结合分子来提高捕获探针的密度，或者如此处所述，通过使用功能化聚合物将其他引发剂直接偶联至检测试剂。为此，我们以前考虑过聚（丙烯酸-共-丙烯酰胺）骨架。以曙红为光引发剂，这些努力受到溶解度限制的阻碍。在这里，我们使用聚（酰胺基胺）树状聚合物作为支架，以产生具有增强的溶解度的结合物。通过对这些结合物的表面结合和溶液相性质的研究，我们表明淬灭作用影响这些结合物作为大光引发剂的功效。

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