A novel, efficient and sustainable strategy for the synthesis of alpha-glycoconjugates by combination of a alpha-galactosynthase and a green solvent

Bayon C.; Moracci M.; Hernaiz M. J.

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A novel, efficient and sustainable strategy for the synthesis of alpha-glycoconjugates by combination of a alpha-galactosynthase and a green solvent

机译：通过结合α-半乳糖合酶和绿色溶剂合成α-糖共轭物的新颖，有效和可持续的策略

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Glycosynthases are becoming important enzymatic tools for the synthesis of oligosaccharides. Herein, we explore for the first time the synthesis of alpha-glycoconjugates using a alpha-glycosynthase in green solvents. Using this biocatalyst, beta-Gal-N3 as donor, pNP-Glc and pNP-Man as acceptors, and green co-solvents we obtained high yields and excellent selectivities in the synthesis of alpha-glycoconjugates. In addition, reaction scale-up is feasible and co-solvent can be recovered and reused, increasing the sustainability of the reaction process. The results demonstrate that the combination of a glycosynthase and a green solvent is a promising alternative for the synthesis of glycoconjugates. The non-hydrolytic capability of this enzyme on the product obtained is a key feature that can be expanded to other glycosynthases.

机译：糖苷合酶正在成为合成寡糖的重要酶促工具。在本文中，我们首次探索了在绿色溶剂中使用α-糖基合成酶合成α-糖基共轭物的方法。使用这种生物催化剂，β-Gal-N3作为供体，pNP-Glc和pNP-Man作为受体，以及绿色助溶剂，我们在合成α-糖缀合物时获得了高收率和出色的选择性。此外，扩大反应规模是可行的，并且可以回收和再使用助溶剂，从而提高了反应过程的可持续性。结果表明，糖合酶和绿色溶剂的组合是糖缀合物合成的有前途的替代方法。该酶对获得的产物的非水解能力是关键特征，可以扩展到其他糖合酶。

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《RSC Advances》 |2015年第68期|共8页
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Bayon C.; Moracci M.; Hernaiz M. J.;
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中图分类化学;
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1. A novel, efficient and sustainable strategy for the synthesis of alpha-glycoconjugates by combination of a alpha-galactosynthase and a green solvent [J] . Bayon C., Moracci M., Hernaiz M. J. RSC Advances . 2015,第68期

机译：通过结合α-半乳糖合酶和绿色溶剂合成α-糖共轭物的新颖，有效和可持续的策略
2. A green and efficient method for the synthesis of pyrroles using a deep eutectic solvent ([CholineCl][ZnCl2](3)) under solvent-free sonication [J] . Hai Truong Nguyen, Duy-Khiem Nguyen Chau, Phuong Hoang Tran New Journal of Chemistry . 2017,第21期

机译：在无溶剂的超声处理下使用深共晶溶剂（[Cholinecl] [ZnCl2]（3））来合成吡咯的绿色有效方法
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机译：InCl_3-CH_3CN-H_2O：一种有效的催化剂-溶剂组合，用于合成Perlin醛和相关化合物。在合成非天然l-天竺葵中的应用
4. A Green and Sustainable Solution for Treating and Controlling Chlorinated Solvent Groundwater Plumes [C] . Regina Butler, Mark Kershner, Paul Goldsmith International Conference on Remediation of Chlorinated and Recalcitrant Compounds . 2014

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机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
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机译：在无溶剂条件下通过预热的粉煤灰预热的粉煤灰催化环化进行格林，简单，高效地合成一些恶唑催化环化

A novel, efficient and sustainable strategy for the synthesis of alpha-glycoconjugates by combination of a alpha-galactosynthase and a green solvent

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