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首页> 外文期刊>RSC Advances >Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma
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Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma

机译：普鲁士蓝纳米笼中高效装载阿霉素用于光热/化学疗法联合治疗肝细胞癌

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Prussian Blue-based nanoparticles have been explored as the new generation of NIR-driven photothermal conversion agents (PTCAs) for cancer treatment. However, PTT treatment alone has limited therapeutic efficiency since it could not eliminate tumor cells completely. In this paper, we synthesized Prussian Blue nanocages (PBNCs) loaded with doxorubicin (DOX) (referred to as PBNCs-DOX nanocomposites) as efficient drug delivery vehicles, combining the photothermal therapy function of Prussian Blue and the chemotherapy function of DOX to enhance the therapeutic efficiency against hepatocellular carcinoma (HCC). The prepared PBNCs-DOX nanocomposites were characterized by TEM and FT-IR spectroscopy. Fluorescence intensity (FI) measurements determined that the loading content of DOX in PBNCs was as high as 33.0 wt% and that the loading efficiency was up to 88.4%. The DOX release from the PBNCs could be triggered by the environmental pH and near infra-red (NIR) laser irradiation. An in vitro cytotoxicity assay demonstrated that the PBNCs-DOX nanocomposites had significantly higher killing efficacy against HepG2 cells in the presence of NIR irradiation, than those in the absence of NIR irradiation or those in the presence of NIR irradiation but treated with PBNCs rather than PBNCs-DOX nanocomposites. Therefore, PBNCs-DOX nanocomposites, which have integrated the photothermal therapy with the chemotherapy, might serve as promising dual-mode therapeutic agents for HCC treatment in the future.
机译：基于普鲁士蓝的纳米颗粒已被研究为新一代的NIR驱动的光热转化剂（PTCA），用于治疗癌症。但是，仅PTT治疗不能完全消除肿瘤细胞，因此治疗效果有限。在本文中，我们合成了载有阿霉素（DOX）的普鲁士蓝纳米笼（PBNC）（称为PBNCs-DOX纳米复合材料）作为有效的药物递送载体，结合了普鲁士蓝的光热治疗功能和DOX的化疗功能来增强对肝细胞癌（HCC）的治疗效率。通过TEM和FT-IR光谱对制备的PBNCs-DOX纳米复合材料进行表征。荧光强度（FI）测量确定PBNC中DOX的负载量高达33.0 wt％，负载效率高达88.4％。 PBNC中DOX的释放可能受到环境pH值和近红外（NIR）激光辐射的触发。体外细胞毒性试验表明，在无近红外辐射的情况下，PBNCs-DOX纳米复合材料对HepG2细胞的杀伤力明显高于无近红外辐射或有近红外辐射但用PBNC而不是PBNC处理的人-DOX纳米复合材料。因此，将光热疗法与化学疗法相结合的PBNCs-DOX纳米复合材料将来可能成为有希望的用于HCC治疗的双模式治疗剂。

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