Phialomustin A-D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea

Nalli Yedukondalu; Mirza Dania N.; Wani Zahoor A.; Wadhwa Bhumika; Mallik Fayaz A.; Raina Chand; Chaubey Asha; Riyaz-Ul-Hassan Syed; Ali Asif

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Phialomustin A-D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea

机译：Phialomustin A-D，一种内生真菌，Philophora mustea的新的抗微生物和细胞毒性代谢产物

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Phialomustin A-D (1-4), four new bioactive metabolites, with an unprecedented azaphilone derived skeleton, were isolated and characterized from an endophytic fungus isolated from Crocus sativus. The ITS-5.8S-ITS2 ribosomal gene sequence of the endophyte displayed a sequence similarity of more than 99% with Phialophora mustea. The structural determinations of compounds (1-4) were authenticated by spectroscopic and chemical analysis. The absolute configuration of the stereogenic centers of 1, 3 and 4 were determined by electronic circular dichroism spectroscopy. Compounds 3 and 4 showed promising antifungal activities against Candida albicans, with IC50 values of 14.3 and 73.6 mu M, whereas compound 2 exhibited remarkable cytotoxic activity against the human breast cancer cell line, T47D, with an IC50 of 1 mu M.

机译：从从番红花中分离出的一种内生真菌分离并鉴定了具有新的生物活性代谢产物Phialomustin A-D（1-4），该代谢物具有空前的氮杂酚酮骨架。内生植物的ITS-5.8S-ITS2核糖体基因序列与毛霉菌的序列相似性超过99％。化合物（1-4）的结构测定通过光谱和化学分析进行鉴定。 1、3和4的立体异构中心的绝对构型是通过电子圆二色性光谱法确定的。化合物3和4对白念珠菌显示出有希望的抗真菌活性，IC50值为14.3和73.6μM，而化合物2对人乳腺癌细胞系T47D表现出显着的细胞毒性活性，IC 50为1μM.

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《RSC Advances》 |2015年第115期|共6页
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Nalli Yedukondalu; Mirza Dania N.; Wani Zahoor A.; Wadhwa Bhumika; Mallik Fayaz A.; Raina Chand; Chaubey Asha; Riyaz-Ul-Hassan Syed; Ali Asif;
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1. Phialomustin A-D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea [J] . Nalli Yedukondalu, Mirza Dania N., Wani Zahoor A., RSC Advances . 2015,第115期

机译：Phialomustin A-D，一种内生真菌，Philophora mustea的新的抗微生物和细胞毒性代谢产物
2. Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense [J] . Duan Xiao-Xiang, Qin Dan, Song Hong-Chuan, Phytochemistry Letters . 2019,第期

机译：IRPEXLACTE A-D，来自耐涝植物的内胚菌IRPEX Lacteus DR10-1的四种新的生物活性代谢物。
3. Chaetoglocins A-D, four new metabolites from the endophytic fungus Chaetomium globosum. [J] . Ge HM, Zhang Q, Xu SH, Planta medica: Natural products and medicinal plant research . 2011,第3期

机译：Chaetoglocins A-D，来自内生真菌球壳Chaetomium globosum的四种新代谢产物。
4. Antimicrobial additives from endophytic fungus Fusarium solani of Ficus carica [C] . Hongchi Zhang, Yangmin Ma, Rui Liu International Conference on Civil Engineering, Architecture and Building Materials . 2012

机译：来自Ficus Carica的内啡会真菌镰刀菌的抗菌添加剂
5. Detoxification of corn antimicrobial compounds by the endophytic fungus Fusarium verticillioides and the significance to plant-fungus interactions. [D] . Glenn, Anthony Elbie. 2001

机译：内生真菌Fusarium verticillioides对玉米抗菌化合物的解毒作用及其对植物-真菌相互作用的意义。
6. Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus [O] . Sidhartha Taritla, Madhuree Kumari, Siya Kamat, 2021

机译：用于生产细胞毒性二次代谢物和凋亡诱导活性的物理化学参数的优化藻类衍生内生真菌的培养提取物
7. Pestalotheols A-D, Bioactive Metabolites from the Plant Endophytic Fungus Pestalotiopsis theae [O] . Erwei Li, Renrong Tian, Shuchun Liu, 2007

机译：pestalotheols a-D，来自植物内生真菌pestalotiopsisae的生物活性代谢物

Phialomustin A-D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea

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