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首页> 外文期刊>RSC Advances >Tumor cell responses to carbon dots derived from chondroitin sulfate
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Tumor cell responses to carbon dots derived from chondroitin sulfate

机译：肿瘤细胞对源自硫酸软骨素的碳点的反应

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摘要

Mass production of carbon dots (CDs) derived from chondroitin sulfate (CS) was developed by the facile hydrothermal approach for the first time. The CS derived CDs (CSCDs) possessed good dispersibility and water solubility, bright blue and green luminescence, and relative pH- and photo-stable properties. Moreover, the multicolor CSCDs could be efficiently uptaken by SAS cells and exhibited low cytotoxicity. Therefore, the responses of human oral squamous cell carcinoma SAS cells to CSCDs were further investigated by evaluating their proliferation and invasion. Compared to CS, CSCDs not only provided higher efficiency for proliferation of SAS cells, and up-regulated expression of matrix metalloproteinases to mimic extracellular matrix secretion, but also portrayed fluorescence for labeling SAS tumor cells. Hence, the multifunctional CSCDs are expected to have potential for biomedical applications.
机译：通过简便的水热方法首次开发了源自​​硫酸软骨素（CS）的碳点（CD）的批量生产。 CS衍生CD（CSCD）具有良好的分散性和水溶性，明亮的蓝色和绿色发光以及相对的pH和光稳定特性。此外，多色CSCDs可以被SAS细胞有效摄取，并显示出低细胞毒性。因此，通过评估它们的增殖和侵袭，进一步研究了人类口腔鳞状细胞癌SAS细胞对CSCD的应答。与CS相比，CSCD不仅为SAS细胞的增殖提供了更高的效率，并且通过上调基质金属蛋白酶的表达来模仿细胞外基质的分泌，还为标记SAS肿瘤细胞描绘了荧光。因此，多功能CSCD有望在生物医学应用中具有潜力。

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