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首页> 外文期刊>RSC Advances >Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers - a review
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Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers - a review

机译：槲皮素在抗糖尿病研究中和基于聚合物的载体改善槲皮素生物利用度的策略-综述

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With numerous pharmacological and biological functions bio-flavonoids gain appreciable attention in diabetes and other therapeutic research. Among several beneficial flavonoids quercetin exhibits impressive hypoglycemic effects, with significant improvement, stabilization of long sustaining insulin secretion and regeneration of human islets in the pancreas without producing serious health hazards. However, in oral delivery poor solubility, stability in biological milieu, low permeation, short biological half-life, and insignificant bioavailability limit its wide application in anti diabetic research. Over the last few decades polymeric carrier systems have been widely studied for improvement of quercetin bioavailability. Natural polymers are more preferred in this regard as they possess several favourable properties like biocompatibility, biodegradability, mucoadhesiveness, non-immunogenicity and non-toxicity. This review focuses on quercetin in anti-diabetic research and the progress in the synthesis of polymer-based formulations for efficient quercetin delivery, with an emphasis on producing an improved biological efficacy of the flavonoid. Diabetic complications, probable mechanisms of quercetin absorption, regulation and anti diabetic effects, obstacles to produce desired bio-efficacy and possible remedies are also brought into focus. To overcome these barriers encapsulation of quercetin within various safe polymeric vehicles are discussed. Further, this review sheds light on enhancing the efficacy of quercetin in novel ways for successful diabetes treatment and others.
机译：具有多种药理和生物学功能的生物类黄酮在糖尿病和其他治疗研究中引起了极大的关注。在几种有益的类黄酮中，槲皮素具有令人印象深刻的降血糖作用，在不产生严重健康危害的情况下，具有显着的改善作用，稳定的胰岛素持续长效分泌以及胰腺中人胰岛的再生。但是，口服给药的溶解性差，在生物环境中的稳定性，低渗透性，短的生物半衰期和微不足道的生物利用度限制了其在抗糖尿病研究中的广泛应用。在过去的几十年中，已经广泛研究了聚合物载体系统以改善槲皮素的生物利用度。在这方面，天然聚合物是更优选的，因为它们具有几种有利的性质，例如生物相容性，生物降解性，粘膜粘附性，非免疫原性和无毒性。这篇综述的重点是抗糖尿病研究中的槲皮素以及用于高效槲皮素递送的基于聚合物的配方合成方面的进展，重点是提高类黄酮的生物功效。糖尿病并发症，槲皮素吸收的可能机制，调节和抗糖尿病作用，产生所需生物功效的障碍以及可能的治疗方法也成为关注焦点。为了克服这些障碍，讨论了槲皮素在各种安全的聚合物载体中的包封。此外，本综述阐明了以新颖的方式增强槲皮素的功效以成功治疗糖尿病等。

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