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首页> 外文期刊>RSC Advances >In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography
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In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography

机译：多光谱光声层析成像技术研究星形和棒状金纳米粒子的体内药代动力学特征和生物分布

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Metallic nanomaterials, especially gold nanoparticles, which have low toxicity and high photothermal conversion efficiency, exhibit promising theranostic applications in biomedical fields. However, detailed preclinical studies of these nanomaterials, such as pharmacokinetics, metabolism, long-term stability and toxicity potential should still be performed. Photoacoustic imaging as a novel non-invasive imaging technique provides convenience for studying real-time semiquantitative pharmacokinetic and biodistribution profiles of drugs or probes to determine whether they can reach the target areas and their metabolic pathways. In this article, we prepared chitosan-capped star shaped gold nanoparticles (AuNSs) and used multispectral optoacoustic tomography (MSOT) to visualize AuNSs in the blood vessels, liver, spleen and kidneys in real time. We also compared these results with chitosan-capped rod shaped gold nanoparticles (AuNRs). The results show that both AuNSs and AuNRs experience rapid blood clearance and have fast and long-term accumulation in the liver and spleen (reaching the peak value within 10 min). The pharmacokinetic data of the two gold nanoparticles fitted to the two-compartment model. The important pharmacokinetic parameters were calculated. The results from MSOT were qualitatively validated by inductively coupled plasma mass spectrometery (ICP-MS). Our results demonstrate that MSOT can serve as an effective tool to monitor gold nanoparticles' pharmacokinetics and biodistribution in specific organs.
机译：具有低毒性和高光热转化效率的金属纳米材料，特别是金纳米颗粒，在生物医学领域显示出有前景的治疗学应用。但是，仍应对这些纳米材料进行详细的临床前研究，例如药代动力学，代谢，长期稳定性和毒性潜力。光声成像作为一种新型的非侵入性成像技术，为研究药物或探针的实时半定量药代动力学和生物分布图，以确定它们是否可以到达目标区域及其代谢途径提供了便利。在本文中，我们制备了壳聚糖封顶的星形金纳米颗粒（AuNSs），并使用多光谱光声层析成像（MSOT）实时可视化了血管，肝脏，脾脏和肾脏中的AuNSs。我们还将这些结果与壳聚糖封端的棒状金纳米颗粒（AuNRs）进行了比较。结果表明，AuNS和AuNRs都具有快速的血液清除功能，并且在肝脏和脾脏中具有快速且长期的积累（在10分钟内达到峰值）。拟合到两室模型的两种金纳米颗粒的药代动力学数据。计算了重要的药代动力学参数。 MSOT的结果已通过电感耦合等离子体质谱（ICP-MS）进行了定性验证。我们的结果表明，MSOT可作为监测金纳米颗粒在特定器官内的药代动力学和生物分布的有效工具。

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