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Studies on the physico-chemical characteristics of collagen-pectin composites

机译：胶原-果胶复合材料的理化特性研究

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Collagen is a well-known soft tissue utilized as a scaffold material for wound healing, however it is mechanically feeble and prone to rapid degradation in its native state. In order to overcome this, the collagen forms complexes with natural or synthetic stabilizing agents for different applications. For diabetic wound dressings, research focuses on cross-linking compounds with anti-glycation activity as they act as a potential therapeutic agent for wound healing. The current study aims to assess whether pectin can be one of the constituents during collagen scaffold preparation. Experimental and theoretical work suggest that pectin can act as a compatible component for collagen in formulating a scaffold, with an increase in thermal stability of about 14 degrees C compared to native collagen (62 degrees C). Pectin induces collagen aggregation due to its charged nature and tends to aggregate quickly in an ordered way. This helps to combat excess glycosylation of collagen. There is a minor loss of crystallinity and variations in the functional groups of collagen due to pectin. Morphological evaluation through SEM and AFM are used to characterize the influence of pectin in structural variations of collagen fibrils. Morphological evaluation confirms that there are significant changes in the fibrillogenesis, however the gelling nature of pectin influences uniform film formation. Moreover, pectin acts as an efficient inhibitor for resisting the action of collagenase on collagen and in turn, increases its structural stability. Computational studies also confirm the fact that pectin can act as a suitable ligand for collagen. Moreover, the study confirms that pectin predominantly interacts with basic amino acids which act as competitive agents to sugars during the glycosylation process. The current investigation helps to establish new avenues in collagen tissue engineering applications for diabetic treatment.
机译：胶原蛋白是众所周知的软组织，用作用于伤口愈合的支架材料，但是它在机械上微弱并且易于在其天然状态下快速降解。为了克服这个问题，胶原蛋白与天然或合成稳定剂形成复合物以用于不同的应用。对于糖尿病伤口敷料，研究重点是具有抗糖基化作用的化合物的交联，因为它们可作为伤口愈合的潜在治疗剂。目前的研究旨在评估果胶在胶原蛋白支架制备过程中是否可以作为成分之一。实验和理论工作表明，果胶可以在配制支架时充当胶原蛋白的相容成​​分，与天然胶原蛋白（62摄氏度）相比，其热稳定性提高了约14摄氏度。果胶由于其带电性质而诱导胶原蛋白聚集，并且倾向于以有序的方式快速聚集。这有助于对抗胶原蛋白的过度糖基化。由于果胶而导致的结晶度损失很小，胶原的功能基团也发生了变化。通过SEM和AFM进行形态学评估可表征果胶对胶原纤维结构变化的影响。形态学评估证实原纤维形成有显着变化，但是果胶的胶凝性质影响均匀的膜形成。此外，果胶充当抵抗胶原酶对胶原的作用的有效抑制剂，并反过来增加其结构稳定性。计算研究还证实了果胶可以充当胶原蛋白的合适配体的事实。此外，该研究证实果胶主要与碱性氨基酸相互作用，而碱性氨基酸在糖基化过程中充当糖的竞争剂。目前的研究有助于在胶原组织工程应用中为糖尿病治疗建立新的途径。

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