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首页> 外文期刊>RSC Advances >Silk fibroin tissue engineering scaffolds with aligned electrospun fibers in multiple layers
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Silk fibroin tissue engineering scaffolds with aligned electrospun fibers in multiple layers

机译：丝素蛋白组织工程支架，多层对齐的电纺纤维

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摘要

Silk-based materials have great potentials in medical applications because of the proper mechanical properties and outstanding biocompatibility. This paper reports a novel method to prepare multi-layered silk fibroin (SF) tissue engineering scaffolds with well-aligned fibers oriented in different angles by an electrospinning process. The resulted aligned fibers construct the scaffolds with a grill-like structure, large area and improved mechanical properties, which have been demonstrated by scanning electron microscopy and tensile test. Biocompatibility analysis proves that the grill-like structure well guides the adhesion, proliferation and differentiation of porcine iliac endothelial cells along the aligned SF fibers in different directions.
机译：丝绸基材料由于具有适当的机械性能和出色的生物相容性，在医学应用中具有巨大的潜力。本文报道了一种新颖的方法，该方法通过静电纺丝工艺制备了具有良好排列的纤维且方向不同的取向的多层丝素蛋白（SF）组织工程支架。所得的排列的纤维构成具有格栅状结构，大面积和改善的机械性能的支架，这已经通过扫描电子显微镜和拉伸试验证明。生物相容性分析证明，格栅状结构很好地引导猪内皮细胞沿着排列的SF纤维在不同方向上粘附，增殖和分化。

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