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Amperometric sensing of urea using edge activated graphene nanoplatelets

机译：边缘活化石墨烯纳米片对尿素的安培感测

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摘要

Sensing of urea is the key component in the diagnosis of kidney related diseases and milk adulteration. Until now, the methods developed for urea sensing are not easy to perform, and very little attention has been paid to commercialization of such sensors. Herein, for the first time we report the low cost graphene nanoplatelets (GNPlts) based sensing platform for urea. Specifically edge functionalized GNPlts are used for keeping graphitic activity of graphene planes intact. We have successfully sensed variable ranges of urea concentrations from 0.1-0.8 mg ml(-1). The amperometeric characterization showed a linear variation in current as a function of urea concentration. The developed platform has a rapid response time of 15 s with good sensitivity (33 mu A (mg ml(-1))(-1)) and specificity. This developed nanoplatform could be highly beneficial for the development of an ultrasensitive, disposable, routine use sensor for urea.
机译：尿素的检测是诊断肾脏相关疾病和牛奶掺假的关键组成部分。到目前为止，开发用于尿素感测的方法并不容易执行，并且很少关注这种传感器的商业化。在本文中，我们首次报告了基于低成本石墨烯纳米血小板（GNPlts）的尿素传感平台。特别地，边缘官能化的GNPlts用于保持石墨烯平面的石墨活性完整。我们已经成功地检测到尿素浓度在0.1-0.8 mg ml（-1）之间的可变范围。电流安培特性显示电流随尿素浓度的变化而线性变化。开发的平台具有15 s的快速响应时间，具有良好的灵敏度（33μA（mg ml（-1））（-1））和特异性。这种开发的纳米平台对于开发超灵敏，一次性使用的尿素常规传感器可能非常有利。

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