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Bidirectional regulation of zinc embedded titania nanorods: antibiosis and osteoblastic cell growth

机译：锌嵌入二氧化钛纳米棒的双向调节：抗菌作用和成骨细胞生长

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New generation bone implants with favourable biocompatibility and long-term antibacterial activity have attracted a great deal of attention due to their bifunctional regulation on osteogenesis and antibiosis, demonstrating great potential for their application in biomedical science. In this study, Zn-incorporated TiO2 nanoarrays are prepared by a hydrothermal approach and the Zn content in the nanorod-structure scaffolds can be controlled by altering the concentration of the precursor solution, thereby tailoring the Zn incorporated scaffolds to meet the requirements in bifunctional clinical applications. Cytocompatibility of the Zn-incorporated TiO2 nanoarrays was evaluated by MTT, LDH and ALP assays, and all the results are found to be dependent on both time and Zn content. Among TiO2-Zn nanoarrays, TiO2-Zn0.2 has the most remarkably stimulative effects on MC3T3-E1 cells compared to untreated controls. Meanwhile, the antibacterial tests confirm that the hybrid nanoarrays can exert inhibitory effects on Escherichia coli (E. coli, Gram-negative) and Staphylococcus aureus (S. aureus, Gram-positive) to various degrees based on time and Zn content. The bifunctional implant materials that allow sustainable Zn release with both superior biocompatibility and long-term antibacterial properties will hold significant promise for scalable productions and open the horizon for further applications as biomedical devices.
机译：具有良好生物相容性和长期抗菌活性的新一代骨植入物因其对成骨和抗菌作用的双功能调节而备受关注，这表明它们在生物医学中的应用潜力很大。在这项研究中，通过水热法制备了掺锌的TiO2纳米阵列，可以通过改变前体溶液的浓度来控制纳米棒结构支架中的锌含量，从而定制掺锌的支架以满足双功能临床的要求。应用程序。通过MTT，LDH和ALP分析评估了掺锌的TiO2纳米阵列的细胞相容性，发现所有结果均取决于时间和锌含量。在TiO2-Zn纳米阵列中，与未处理的对照组相比，TiO2-Zn0.2对MC3T3-E1细胞具有最显着的刺激作用。同时，抗菌测试证实，基于时间和锌含量，杂化纳米阵列可以对大肠杆菌（E. coli，革兰氏阴性）和金黄色葡萄球菌（S. aureus，革兰氏阳性）发挥不同程度的抑制作用。具有优异的生物相容性和长期抗菌性能的可持续锌释放的双功能植入材料将为可扩展的生产量提供巨大的希望，并为生物医学设备的进一步应用打开了广阔的前景。

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