An odorless, one-pot synthesis of nitroaryl thioethers via SNAr reactions through the in situ generation of S-alkylisothiouronium salts

Lu Guo-ping; Cai Chun

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An odorless, one-pot synthesis of nitroaryl thioethers via SNAr reactions through the in situ generation of S-alkylisothiouronium salts

机译：通过SNAr反应通过原位生成S-烷基异硫脲盐进行无味一锅合成硝基芳基硫醚

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A newly developed C-S bond formation nucleophilic aromatic substitution (SNAr) reaction in aqueous Triton X-100 (TX100) micelles has been disclosed. This chemistry, in which odorless, cheap and stable thiourea in place of thiols is used as the sulfur reagent, provides an efficient approach for the generation of nitroaryl thioethers, which are useful structural units of many bioactive molecules, rendering this methodology attractive to both synthetic and medicinal chemistry.

机译：已公开了在水性Triton X-100（TX100）胶束中新开发的C-S键形成亲核芳香取代（SNAr）反应。该化学方法使用无味，廉价且稳定的硫脲代替硫醇作为硫试剂，为产生硝基芳基硫醚提供了一种有效的方法，硝基芳基硫醚是许多生物活性分子的有用结构单元，使该方法对两种合成方法都具有吸引力和药物化学。

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《RSC Advances》 |2014年第104期|共7页
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Lu Guo-ping; Cai Chun;
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正文语种 eng
中图分类化学;
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1. An odorless, one-pot synthesis of nitroaryl thioethers via SNAr reactions through the in situ generation of S-alkylisothiouronium salts [J] . Lu Guo-ping, Cai Chun RSC Advances . 2014,第104期

机译：通过SNAr反应通过原位生成S-烷基异硫脲盐进行无味一锅合成硝基芳基硫醚
2. Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water [J] . Zhong-qing Wang, Ze-mei Ge, Tie-ming Cheng, Synlett . 2009,第12期

机译：丙二腈与醛和S-烷基异硫脲盐在水中的一锅，三组分级联反应合成高度取代的吡啶
3. Multiple Approaches to the In Situ Generation of Anhydrous Tetraalkylammonium Fluoride Salts for SNAr Fluorination Reactions [J] . Cismesia Megan A., Ryan Sarah J., Bland Douglas C., The Journal of Organic Chemistry . 2017,第10期

机译：用于氟化反应的无水四烷基氟化铵盐的多种方法
4. One-Pot Reaction for Synthesis of 1, 2, 3-Triazole Thioethers from lodotriazole, Sulfur and Alkylhalides/Tosylates [C] . Bei Yang, Yi-ning Wen, Zhen Jiang, International Symposium on Energy Science and Chemical Engineering . 2015

机译：合成1,2,3-三唑硫醚的单罐反应来自洛替三唑，硫和烷基卤化物/甲苯磺酸酯
5. I. Steric effects in the synthesis of 2,3-dihydro-4-(1H)-quinolinones by the tandem Michael-SNAr reaction. II Synthesis of nitrogen heteroarotinoids for anticancer activity. III. Synthetic study of supramolecular compounds [D] . Abuskhuna, Suaad M. 2013

机译：I.通过串联Michael-SNAr反应合成2，3-二氢-4-（1H）-喹啉酮的立体效应。 II。合成氮杂芳烃类化合物具有抗癌活性。三，超分子化合物的合成研究
6. Solvent- and Catalyst-Free One-Pot Green Bound-TypeFused Bis-Heterocycles Synthesis via Groebke–Blackburn–BienayméReaction/SNAr/Ring-Chain Azido-Tautomerization Strategy [O] . MiguelÁngel Claudio-Catalán, Shrikant G. Pharande, Andrea Quezada-Soto, 2018

机译：不含溶剂和催化剂的一罐绿色粘合剂Groebke–Blackburn–Bienaymé的熔融双杂环合成反应/ SNAr /环链叠氮基互变异构策略
7. Odorless regioselective ring opening of epoxides with S-alkylisothiouronium salts as masked thiols in water [O] . Rajib Panchadhayee, Anup Kumar Misra 2009

机译：环氧化物的无气味区域选择性开环，用s-烷基异硫脲盐作为水中的掩蔽硫醇

An odorless, one-pot synthesis of nitroaryl thioethers via SNAr reactions through the in situ generation of S-alkylisothiouronium salts

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