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首页> 外文期刊>RSC Advances >Fluorescent micellar nanoparticles by self-assembly of amphiphilic, nonionic and water self-dispersible polythiophenes with 'hairy rod' architecture
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Fluorescent micellar nanoparticles by self-assembly of amphiphilic, nonionic and water self-dispersible polythiophenes with 'hairy rod' architecture

机译：通过具有“毛杆”结构的两亲，非离子和水自分散性聚噻吩的自组装而形成的荧光胶束纳米颗粒

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摘要

Polymers with "hairy-rod" architecture having oligo/polythiophene (PTh) as main chain and poly (ethylene glycol) (PEG) (M-n = 2000) as flexible side chains were obtained by combining the "macromonomer technique" with specific methods for the synthesis of conjugated polymers. Fluorescent nanoparticles of core-shell type with high colloidal stability were obtained from these water self-dispersible materials by a direct dissolution method in aqueous media. It has been shown that the size and photophysical properties of the micellar nanoparticles in aqueous dispersions as well as the bulk properties of the investigated materials can be tuned by varying the PEG side chain density and by the modality of PEG connection to the PTh main chains. The presence of the PEG shells in the structure of these fluorescent nanoparticles cans suppress the non-specific interactions with biomolecules on the one side and on the other side they work as a biomimetic interface that could facilitate their potential use as cell-imaging agents. The present attempt offers an ease of access alternative to conducting polymer nanoparticle encapsulation in a biocompatible matrix by nanoprecipitation.
机译：通过将“大分子单体技术”与特定方法结合使用，可得到具有“毛杆”结构的聚合物，该结构具有低聚/聚噻吩（PTh）作为主链，聚乙二醇（PEG）（Mn = 2000）作为柔性侧链。共轭聚合物的合成。这些水自分散性材料通过直接溶解在水性介质中而得到胶体稳定性高的核壳型的荧光纳米粒子。已经显示，可以通过改变PEG侧链密度和通过PEG连接至PTh主链的方式来调节水分散体中的胶束纳米颗粒的尺寸和光物理性质以及所研究材料的整体性质。这些荧光纳米颗粒结构中PEG壳的存在可以一方面抑制与生物分子的非特异性相互作用，另一方面，它们作为仿生界面起作用，可以促进它们潜在用作细胞成像剂。本尝试为通过纳米沉淀在生物相容性基质中进行聚合物纳米颗粒封装提供了容易的替代方法。

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