A selective fluorescent probe for cysteine and its imaging in live cells

Kim Youngsam; Choi Minsuk; Seo Seokjun; Manjare Sudesh T.; Jon Sangyong; Churchill David G.

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A selective fluorescent probe for cysteine and its imaging in live cells

机译：半胱氨酸的选择性荧光探针及其在活细胞中的成像

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A probe for the detection of cysteine over homocysteine based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) was prepared and used in confocal microscopy experiments. The probe was designed to block excited state intramolecular proton transfer (ESIPT). When bromopropionyl group protection is removed, HBT is recovered via nucleophilic substitution and intramolecular cyclization. The probe was found to have a detection limit of 2.8 mu M and exhibits a similar to 20-fold increase. The probe showed cell membrane permeability and efficacy in living Hep3B cells.

机译：制备了一种基于2-（2'-羟基苯基）苯并噻唑（HBT）的高半胱氨酸检测半胱氨酸的探针，并将其用于共聚焦显微镜实验。该探针设计用于阻止激发态分子内质子转移（ESIPT）。除去溴丙酰基保护后，HBT可通过亲核取代和分子内环化作用回收。发现该探针的检测极限为2.8μM，并且表现出相似的增加20倍。该探针显示了在活Hep3B细胞中的细胞膜通透性和功效。

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《RSC Advances》 |2014年第109期|共4页
作者
Kim Youngsam; Choi Minsuk; Seo Seokjun; Manjare Sudesh T.; Jon Sangyong; Churchill David G.;
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正文语种 eng
中图分类化学;
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1. A selective fluorescent probe for cysteine and its imaging in live cells [J] . Kim Youngsam, Choi Minsuk, Seo Seokjun, RSC Advances . 2014,第109期

机译：半胱氨酸的选择性荧光探针及其在活细胞中的成像
2. Ultrafast deep-red emission fluorescent probe for highly selective imaging of endogenous cysteine in living cells and mice [J] . Lu Zhengliang, Lu Yanan, Fan Chunhua, Sensors and Actuators . 2019,第JULa期

机译：超快深红色发射荧光探针，用于活细胞和小鼠中内源性半胱氨酸的高选择性成像
3. Ultrafast deep-red emission fluorescent probe for highly selective imaging of endogenous cysteine in living cells and mice [J] . Lu Zhengliang, Lu Yanan, Fan Chunhua, Sensors and Actuators . 2019,第Jula期

机译：超快深红发射荧光探针，用于活细胞和小鼠中内源性半胱氨酸的高度选择性成像
4. Fluorescent water-Soluble Probes Based on Ammonium Cation Peg Substituted Perylenepisimides: Synthesis, Photophysical Properties, and Live Cell Images [C] . Wei Yang, Jiaxuan Cai, Shuchen Zhang Annual International Conference on Material Science and Environmental Engineering . 2018

机译：基于铵阳离子PEG取代的Per alenEpisides的荧光水溶性探针：合成，光药性和活细胞图像
5. Ratiometric Near-Infrared Fluorescent Probes for the Sensitive Detection of Intracellular pH and Bio-Thiols in Live Cells [D] . Xia, Shuai . 2020

机译：大率近红外荧光荧光探针，用于活细胞中细胞内pH和生物硫醇的敏感性检测
6. A Novel Dicyanoisophorone-Based Ratiometric Fluorescent Probe for Selective Detection of Cysteine and Its Bioimaging Application in Living Cells [O] . Hengrui Zhang, Nan Qin, Zhijie Fang 2018

机译：一种基于双氰基异佛尔酮的比例荧光探针选择性检测半胱氨酸及其在活细胞中的生物成像应用
7. A novel and simple imidazo1,2-apyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish [O] . Meiqing Zhu, Lijun Wang, Xiaoqin Wu, 2019

机译：一种新颖而单纯的咪唑吡嗪荧光荧光荧光探针，用于活细胞和斑马鱼中半胱氨酸的敏感和选择性成像

A selective fluorescent probe for cysteine and its imaging in live cells

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