New MCR based on intramolecular Heck reaction under aerobic conditions: a direct access to cytotoxic fused N-heterocycles

Adepu Raju; Prasad Bagineni; Ashfaq Mohd Ashraf; Ehtesham Nasreen Z.; Pal Manojit

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New MCR based on intramolecular Heck reaction under aerobic conditions: a direct access to cytotoxic fused N-heterocycles

机译：基于有氧条件下分子内Heck反应的新MCR：直接进入细胞毒性融合N-杂环

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We report a new MCR involving the reaction of isatoic anhydrides, allyl amine and o-bromo arylaldehydes in the presence of Pd(OAc)(2), X-Phos and air to afford various isoquinolino[1,2-b]quinazolinones as new cytotoxic agents. The strategy was extended successfully towards the synthesis of a methyl analogue of 7,8-dehydrorutaecarpine.

机译：我们报告了一个新的MCR，涉及在Pd（OAc）（2），X-Phos和空气存在下的等酸酐，烯丙基胺和邻溴芳基醛的反应，从而提供了各种新的异喹啉[1,2-b]喹唑啉酮细胞毒剂。该策略已成功地扩展至7,8-脱氢鲁塔卡普兰的甲基类似物的合成。

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《RSC Advances》 |2014年第90期|共5页
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Adepu Raju; Prasad Bagineni; Ashfaq Mohd Ashraf; Ehtesham Nasreen Z.; Pal Manojit;
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正文语种 eng
中图分类化学;
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1. New MCR based on intramolecular Heck reaction under aerobic conditions: a direct access to cytotoxic fused N-heterocycles [J] . Adepu Raju, Prasad Bagineni, Ashfaq Mohd Ashraf, RSC Advances . 2014,第90期

机译：基于有氧条件下分子内Heck反应的新MCR：直接进入细胞毒性融合N-杂环
2. Ligand Effects in the Synthesis of N-Heterocycles by Intramolecular Heck Reactions [J] . Emma L.Cropper, Andrew J.P.White, Agnes Ford, The Journal of Organic Chemistry . 2006,第4期

机译：分子内Heck反应合成N-杂环的配体效应
3. Ligand Effects in the Synthesis of N-Heterocycles by Intramolecular Heck Reactions [J] . Emma L.Cropper, Andrew J.P.White, Agnes Ford, The Journal of Organic Chemistry . 2006,第4期

机译：分子内Heck反应合成N-杂环的配体效应
4. Solvent-Controlled Cascade Reaction of Ugl/Pd-Catalyzed Intramolecular Divergent C-H Fumctionalization for Regies elective Synthesis of Cyclopropanated N-Heterocycles [C] . Tianyi Shang, Yan Pan, Zhong Chen International Conference on Advanced Composite Materials and Manufacturing Engineering . 2020

机译：UGL / PD催化的溶剂控制级联反应UGL / PD催化分子内发散的C-H富脉冲率的调节选择性合成环丙烷的N-杂环
5. 1. Axially-chiral 7-membered N-heterocyclic carbenes: Synthesis and application to palladium-catalyzed intramolecular aerobic oxidation of olefins 2. Development of palladium-catalyzed aerobic oxidative olefin amination reactions [D] . Scarborough, Christopher C. 2008

机译：1.轴向手性7元N-杂环卡宾：烯烃的钯催化分子内需氧氧化的合成及应用2.钯催化需氧氧化烯烃胺化反应的发展
6. Synthesis of pyrrolidinedione-fused hexahydropyrrolo21-aisoquinolines via three-component 3 + 2 cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions [O] . Xiaoming Ma, Suzhi Meng, Xiaofeng Zhang, 2020

机译：通过三分组分3 + 2环加入合成吡咯烷二酮熔融六氢吡咯烷21-A异喹啉然后是单罐N-烯丙基化和分子内的静脉反应
7. Synthesis of pyrrolidinedione-fused hexahydropyrrolo2,1-aisoquinolines via three-component 3+2 cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions [O] . Xiaoming Ma, Suzhi Meng, Xiaofeng Zhang, 2020

机译：通过三分组分3 + 2环加入合成吡咯烷二酮熔融六氢吡咯烷2,1-A异喹啉，然后是单罐N-烯丙基化和分子内的静脉反应

New MCR based on intramolecular Heck reaction under aerobic conditions: a direct access to cytotoxic fused N-heterocycles

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