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首页> 外文期刊>RSC Advances >Preparation, properties and in vivo pharmacokinetic study of drug vesicles composed of diphenhydramine and AOT
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Preparation, properties and in vivo pharmacokinetic study of drug vesicles composed of diphenhydramine and AOT

机译：苯海拉明与AOT组成的囊泡的制备，性质及体内药代动力学研究

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In this work we designed a controlled-release drug delivery system formed by a cationic drug (diphenhydramine hydrochloride, DH) and an anionic surfactant (sodium 2-ethylhexyl sulfosuccinate, AOT) and investigated the corresponding physicochemical properties, aggregation behavior and potential application in drug delivery systems. The DH-AOT mixed solutions with different molar ratios of DH and AOT at the same total concentration were prepared and characterized. The aggregation behaviors of the drug/surfactant solutions were studied by transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential techniques. Furthermore, hemolysis testing, and in vitro and in vivo drug release were studied to evaluate the potential use of the as-prepared catanionic aggregates in drug delivery systems. The results indicate that the physicochemical properties, the hemolytic toxicity and the drug release behavior are dependent on the composition of the samples, X1 (X1 = n(DH)((DH+AOT))). The results demonstrated that these drug-participating catanionic aggregates show potential as an efficient and safe sustained drug delivery system.
机译：在这项工作中，我们设计了由阳离子药物（盐酸苯海拉明，DH）和阴离子表面活性剂（2-乙基己基磺基琥珀酸钠，AOT）组成的控释药物递送系统，并研究了相应的理化性质，聚集行为和在药物中的潜在应用投放系统。制备并表征了具有相同摩尔浓度的DH和​​AOT摩尔比不同的DH-AOT混合溶液。通过透射电子显微镜（TEM），动态光散射（DLS）和Zeta电位技术研究了药物/表面活性剂溶液的聚集行为。此外，还研究了溶血试验以及体外和体内药物释放，以评估所制备的阳离子聚合体在药物递送系统中的潜在用途。结果表明，理化性质，溶血毒性和药物释放行为取决于样品的组成X1（X1 = n（DH）/ n（（DH + AOT）））。结果表明，这些参与药物的阳离子聚合体显示出作为高效，安全的持续药物递送系统的潜力。

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