Elementary steps in protein folding.

Bieri O; Kiefhaber T

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Elementary steps in protein folding.

机译：蛋白质折叠的基本步骤。

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The mechanism of protein folding is under intense theoretical and experimental investigation. From stopped-flow mixing experiments we have detailed knowledge of processes slower than about 1 ms, but until recently little was known about folding and unfolding reactions on the microsecond to nanosecond time scale. The use of novel techniques allowed to explore the elementary steps in protein folding, such as intrachain diffusion and formation of alpha-helices, beta-hairpins and loop structures. This brief review discusses the time scales of these early elementary events which are crucial for the understanding of how proteins fold.

机译：蛋白质折叠的机制正在深入的理论和实验研究中。从停流混合实验中，我们已经详细了解了慢于约1毫秒的过程，但是直到最近，人们对微秒至纳秒级的折叠和展开反应的了解仍很少。新技术的使用允许探索蛋白质折叠的基本步骤，例如链内扩散和α-螺旋，β-发夹和环结构的形成。这篇简短的评论讨论了这些早期基本事件的时标，这对于理解蛋白质如何折叠至关重要。

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《Biological chemistry》 |1999年第8期|共7页
作者
Bieri O; Kiefhaber T;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Protein Conformation; Protein Folding; Thermodynamics;

机译：蛋白质构象;蛋白质折叠;热力学;

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专利

1. Elementary steps in protein folding. [J] . Bieri O, Kiefhaber T Biological chemistry . 1999,第7a8期

机译：蛋白质折叠的基本步骤。
2. Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions. [J] . Kraemer A, Brinkmann T, Plettner I, Journal of Molecular Biology . 2002,第4期

机译：荧光标记的鸟嘌呤核苷酸结合蛋白可分析GAP催化反应的基本步骤。
3. Early Collapse is not an Obligate Step in Protein Folding. [J] . Jacob J, Krantz B, Dothager RS, Journal of Molecular Biology . 2004,第2期

机译：早期折叠不是蛋白质折叠中的必要步骤。
4. Molecular recognition through local elementary structures: Transferability of simple rnodels to real proteins [C] . R. A. BROGLIA, G. TIANA, D. PROVASI, International School of Physics "Enrico Fermi" . 2007

机译：通过局部基础结构的分子识别：简单rnodels对实际蛋白的可转移性
5. Shaving Levinthal with Occam's razor: Understanding the rate limiting step in protein folding. [D] . Debe, Derek Anthony. 2001

机译：用Occam的剃须刀剃Levinthal：了解蛋白质折叠中的限速步骤。
6. Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins. [O] . Hideaki Fujita, Daisuke Sasaki, Shinichi Ishiwata, 2002

机译：有和没有调节蛋白的牛心肌中跨桥循环的基本步骤。
7. A desolvation barrier to hydrophobic cluster formation may contribute to the rate-limiting step in protein folding. [O] . Rank, J. A., Baker, D. 2008

机译：疏水簇形成的去溶剂化障碍可能有助于蛋白质折叠中的限速步骤。

Elementary steps in protein folding.

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