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首页> 外文期刊>Occupational and environmental medicine >Risk of upper aerodigestive tract cancers in a case-cohort study of autoworkers exposed to metalworking fluids.
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Risk of upper aerodigestive tract cancers in a case-cohort study of autoworkers exposed to metalworking fluids.

机译：在对暴露于金属加工液中的汽车工人进行的病例队列研究中，有上呼吸道消化道癌的风险。

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AIMS: To re-examine aerodigestive cancer risk in a cohort of autoworkers exposed to metal working fluids (MWF), using improved case definition and more recently diagnosed cases. METHODS: The autoworker cohort included 31 100 hourly workers alive on 1 January 1985 who worked at three automobile plants in Michigan. A case-cohort design was carried out that included incident cases of cancers of the larynx, oesophagus, and stomach, and a 10% sample of the cohort. A Cox proportional hazards model was used to estimate MWF exposure effects. The smoothing method of penalised splines was used to explore the shape of the underlying exposure-response curves. RESULTS: The most important finding was the association between larynx cancer incidence and cumulative straight MWF exposure. The results for oesophageal cancer were less consistent. For stomach cancer there was no evidence of excess risk. CONCLUSION: This association between larynx cancer and straight MWF exposures was consistent with a previous finding in this cohort, providing further support for a causal relation.
机译：目的：使用改良的病例定义和最近诊断出的病例，重新检查一组暴露于金属加工液（MWF）的汽车工人的航空消化道癌症的风险。方法：1985年1月1日，该汽车工人队列中有31 100名活着的小时工，他们在密歇根州的三个汽车厂工作。进行了病例队列设计，其中包括喉癌，食道癌和胃癌的意外病例，以及该队列的10％样本。使用Cox比例风险模型估算MWF暴露效应。使用惩罚样条曲线的平滑方法来探索潜在的曝光-响应曲线的形状。结果：最重要的发现是喉癌发生率与累积直接MWF暴露之间的关联。食道癌的结果不一致。对于胃癌，没有证据表明存在过度风险。结论：喉癌与直接MWF暴露之间的这种关联与该队列中以前的发现一致，为因果关系提供了进一步的支持。

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