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首页> 外文期刊>Occupational and environmental medicine >A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
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A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.

机译：对生产食品级双乙酰的化学工作者中肺功能和呼吸道症状的横断面研究。

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OBJECTIVES: Four diacetyl workers were found to have bronchiolitis obliterans syndrome. Exposures, respiratory symptoms, lung function and exposure-response relationships were investigated. METHODS: 175 workers from a plant producing diacetyl between 1960 and 2003 were investigated. Exposure data were used to model diacetyl exposure. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and respiratory symptoms to an internal reference group. RESULTS: Workers were potentially exposed to acetoin, diacetyl, acetaldehyde and acetic acid. Historic diacetyl exposure ranged from 1.8 to 351 mg/m(3), and from 3 to 396 mg/m(3) for specific tasks. Diacetyl workers reported significantly more respiratory symptoms compared to the general population sample (continuous trouble with breathing (prevalence ratio (PR) = 2.6; 95% CI 1.3 to 5.1), daily cough (PR = 1.5; 95% CI 1.1 to 2.1), asthma attack (ever) (PR = 2.0; 95% CI 1.2 to 3.4), doctor diagnosed asthma (PR = 2.2; 95% CI 1.3 to 3.8) and asthma attack in the last year (PR = 4.7; 95% CI 1.9 to 11.4)) and to a minimally exposed internal reference group (ever trouble with breathing (PR = 2.8; 95% CI 1.1 to 7.0) and work-related shortness of breath in the last year (PR = 7.5; 95% CI 1.1 to 52.9)). Lung function did not differ between groups. A positive relationship between exposure and FEV(1) was found. CONCLUSION: The excess of respiratory symptoms in this retrospective cohort suggests that diacetyl production poses an occupational hazard. Limited historical exposure data did not support a quantitative individual diacetyl exposure-response relationship, but our findings suggest that preventive measures are prudent.
机译：目的：发现四名二乙酰工人患有闭塞性细支气管炎综合征。研究了暴露，呼吸道症状，肺功能和暴露-反应关系。方法：对1960年至2003年间生产二乙酰基植物的175名工人进行了调查。暴露数据用于模拟二乙酰暴露。将呼吸功能的肺功能和问卷数据与一般人群样本进行比较，将呼吸系统症状与内部参考组进行比较。结果：工人可能接触了丙酮，二乙酰基，乙醛和乙酸。对于特定任务，历史上的二乙酰暴露范围为1.8至351 mg / m（3），以及3至396 mg / m（3）。与一般人群样本相比，二乙酰工作人员报告的呼吸道症状明显多（持续呼吸困难（患病率（PR）= 2.6; 95％CI 1.3至5.1），每日咳嗽（PR = 1.5; 95％CI 1.1至2.1），哮喘发作（曾经）（PR = 2.0; 95％CI 1.2至3.4），医生诊断为哮喘（PR = 2.2; 95％CI 1.3至3.8）和去年的哮喘发作（PR = 4.7; 95％CI 1.9至11.4））和最低限度暴露的内部参考人群（呼吸困难（PR = 2.8; 95％CI 1.1至7.0）和去年与工作相关的呼吸急促（PR = 7.5; 95％CI 1.1至52.9） ））。两组之间的肺功能没有差异。发现暴露与FEV（1）之间呈正相关。结论：该回顾性队列研究中呼吸道症状过多表明二乙酰生产对职业构成了危害。有限的历史暴露数据不支持定量的个体二乙酰基暴露-反应关系，但我们的发现表明，预防措施是谨慎的。

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