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首页> 外文期刊>Occupational and environmental medicine >Effect of living close to a main road on asthma, allergy, lung function and chronic obstructive pulmonary disease.
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Effect of living close to a main road on asthma, allergy, lung function and chronic obstructive pulmonary disease.

机译：靠近主要道路生活对哮喘，过敏，肺功能和慢性阻塞性肺疾病的影响。

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BACKGROUND: A number of epidemiological studies suggest that the risk of asthma is increased among those living in close proximity to major roads. However, the evidence is inconsistent, and effects on asthma and related respiratory and allergic conditions using objective measures such as lung function and allergic sensitisation have not been widely investigated. METHODS: In 1995, 1996 and 2001 data on respiratory and allergic disease, along with demographic and lifestyle factors, were collected in 59 285 children (aged 2-16 years) and adults as part of the Health Survey for England, a nationally representative annual survey. Using Geographical Information System software, we mapped the location of each participant's home and computed distance to the nearest major road. We estimated the effect of distance on self-reported wheezing in the past year, asthma, eczema and hay fever in 50 994 participants, and on 1-second forced expiratory volume (FEV(1)), immunoglobulin E and spirometry-defined chronic obstructive pulmonary disease (COPD) in subgroups of those aged 7+, 11+ and 16+ years, respectively. RESULTS: Living within 150 m from a major road was not significantly associated with an increased risk of any of the outcome variables in any age group (adjusted odds ratios ranged from 0.85 to 1.05). Furthermore there was little evidence that risk increased with increasing proximity across the 0-150 m range where contrasts in traffic-related pollutant concentrations are greatest. CONCLUSION: Our analysis of a large and nationally representative population sample did not provide evidence of an adverse effect of living in close proximity to main roads on the risk of asthma, COPD or allergic disease in England.
机译：背景：许多流行病学研究表明，居住在靠近主要道路的人中，哮喘的风险增加。但是，证据并不一致，使用诸如肺功能和过敏性致敏等客观措施对哮喘和相关呼吸道和过敏性疾病的影响尚未得到广泛研究。方法：作为全国代表性的英格兰健康调查的一部分，1995年，1996年和2001年收集了59 285名儿童（2-16岁）和成人的呼吸道和过敏性疾病数据以及人口统计和生活方式因素。调查。使用地理信息系统软件，我们绘制了每个参与者的房屋的位置图，并计算了到最近的主要道路的距离。我们估计了距离对过去一年自我报告的喘​​息，哮喘，湿疹和花粉症的影响，共有50 994名参与者，以及1秒强迫呼气量（FEV（1）），免疫球蛋白E和肺活量测定定义的慢性阻塞性疾病的影响分别在7岁以上，11岁以上和16岁以上的人群中患有肺部疾病（COPD）。结果：居住在距主要道路150 m以内的人群与任何年龄段的任何结果变量的风险增加没有显着相关性（调整后的优势比在0.85至1.05之间）。此外，几乎没有证据表明在0-150 m范围内，随着交通相关污染物浓度的差异最大，风险会随着距离的增加而增加。结论：我们对大量具有全国代表性的人口样本的分析没有提供证据证明在英国，靠近主要道路生活对哮喘，COPD或过敏性疾病的风险有不利影响。

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