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Hospital admissions for neurological and renal diseases among dentists and dental assistants occupationally exposed to mercury.

机译：职业性接触汞的牙医和牙医助理因神经系统疾病和肾脏疾病而入院。

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OBJECTIVES: For many years an amalgam containing metallic mercury, which has been associated with neurological and renal diseases, has been used in dentistry. In this nationwide study we compared hospital admissions due to neurological and renal diseases among dentists and dental assistants to admissions in controls. METHODS: This register-based cohort study included all Danish workers employed in dental clinics, general practitioners' clinics or lawyers' offices between 1964 and 2006. We compared dentists with general practitioners and lawyers, and dental assistants with medical secretaries, nurses and legal secretaries. We also compared dentists and dental assistants employed during periods with high occupational mercury exposure with dentists and dental assistants employed during periods with less mercury exposure. We followed all subjects in a nationwide register of hospital admissions. We analysed risk of neurological diseases, Parkinson's disease and renal diseases using a Cox regression model. RESULTS: The cohort consisted of 122,481 workers including 5371 dentists and 33,858 dental assistants. For neurological diseases, no association was observed for dental assistants, while for dentists an increasing risk for periods with less mercury exposure was observed. Among dental assistants, a negative association between employment length and risk of neurological disease was observed. Admissions for renal disease among dental assistants were increased during periods with less mercury exposure compared with controls. For dentists a non-significant increased risk was observed between employment length and renal disease risk. CONCLUSIONS: Our nationwide study does not indicate that occupational exposure to mercury increases the risk of hospital admissions for neurological, Parkinson's or renal diseases.
机译：目的：多年来，牙科中一直使用一种含有金属汞的汞合金，这种汞与神经病学和肾脏疾病有关。在这项全国性的研究中，我们比较了牙医和牙医助理因神经系统疾病和肾脏疾病而导致的医院入院率与对照组的入院率。方法：这项基于登记册的队列研究包括1964年至2006年之间在牙科诊所，全科医生诊所或律师事务所工作的所有丹麦工人。我们将牙医与全科医生和律师进行比较，并将牙科助理与医务秘书，护士和法律秘书进行比较。我们还比较了职业汞暴露量较高的时期聘用的牙医和牙科助手与汞暴露量较少的时期聘用的牙医和牙科助手。我们在全国范围内的入院登记册中跟踪了所有受试者。我们使用Cox回归模型分析了神经系统疾病，帕金森氏病和肾脏疾病的风险。结果：该队列由122,481名工人组成，其中包括5371名牙医和33,858名牙科助手。对于神经系统疾病，没有观察到牙科助手的相关性，而对于牙医来说，汞暴露时间越短的风险越高。在牙科助手中，观察到工作时间和神经系统疾病风险之间存在负相关关系。与对照组相比，在汞暴露较少的时期内，牙科助理的肾脏疾病入院率有所增加。对于牙医来说，在工作时间和肾脏疾病风险之间没有显着增加的风险。结论：我们的全国性研究并未表明职业性接触汞会增加神经病，帕金森氏病或肾病的住院风险。

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