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首页> 外文期刊>Occupational and environmental medicine >Exposures in painting-related occupations and risk of lung cancer among men: results from two case-control studies in Montreal.
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Exposures in painting-related occupations and risk of lung cancer among men: results from two case-control studies in Montreal.

机译：男性中与绘画相关的职业和肺癌的风险暴露：来自蒙特利尔的两项病例对照研究的结果。

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BACKGROUND: Evidence that painters may be at risk for lung cancer comes mainly from analyses on job titles rather than on specific exposures found in the environments of painters. METHODS: In the context of two large population-based case-control studies of lung cancer carried out in Montreal, we were able to assess possible relationships between lung cancer and the occupation of painter as well as exposure to paints, varnishes and stains. Interviews for study I were conducted in 1979-1986 (857 cases, 533 population controls, 1349 cancer controls) and interviews for study II were conducted in 1996-2001 (765 cases and 899 controls). Detailed lifetime job histories were elicited; a team of hygienists and chemists evaluated the evidence of exposure to many occupational substances including paint-related substances. The relative risk of lung cancer was estimated, adjusting for several potential confounders, including smoking, in a three-variable parameterisation. RESULTS: In analyses pooling the two studies, painters had an OR of lung cancer of 1.3 (95% CI 0.9 to 2.2). Regarding exposures, ORs were: for wood varnishes and stains, 1.6 (95% CI 1.0 to 2.3); for wood and gypsum paints, 1.3 (95% CI 0.9 to 1.7); and for metal coatings, 1.1 (95% CI 0.8 to 1.6). Small numbers hampered evaluation of dose-response relationships. CONCLUSIONS: While our results cannot exclude chance or residual confounding by smoking or concomitant occupational exposures, they provide further evidence that some exposures in paint-related occupations, most notably wood varnishes and stains, increase the risk of lung cancer.
机译：背景：画家可能患肺癌的证据主要来自对职称的分析，而不是画家环境中发现的特定暴露因素。方法：在蒙特利尔进行的两项基于肺癌的大型人群病例对照研究中，我们能够评估肺癌与画家的职业以及油漆，清漆和污渍的暴露之间的可能关系。在1979-1986年进行了研究I的访谈（857例，在533个人群中进行了控制，在1349例癌症中进行了研究），在1996-2001年进行了研究II的访谈（在765例中进行了899例）。得出了详细的终生工作经历;一组卫生学家和化学家对暴露于许多职业物质（包括油漆相关物质）的证据进行了评估。估计了肺癌的相对风险，并通过三变量参数化调整了包括吸烟在内的几种潜在混杂因素。结果：在汇总两项研究的分析中，画家的肺癌OR值为1.3（95％CI为0.9至2.2）。关于暴露，OR为：对于木材清漆和污渍，为1.6（95％CI为1.0至2.3）;用于木材和石膏涂料，为1.3（95％CI为0.9至1.7）;金属涂层为1.1（95％CI为0.8至1.6）。数量少阻碍了剂量反应关系的评估。结论：虽然我们的结果不能排除吸烟或伴随的职业接触所带来的机会或残余混杂，但它们提供了进一步的证据，表明与油漆有关的职业中的某些接触，尤其是木清漆和污渍，会增加患肺癌的风险。

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