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首页> 外文期刊>Occupational and environmental medicine >Occupational exposure to diesel engine emissions and risk of lung cancer: Evidence from two case - Control studies in Montreal, Canada
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Occupational exposure to diesel engine emissions and risk of lung cancer: Evidence from two case - Control studies in Montreal, Canada

机译：柴油发动机排放中的职业暴露与肺癌风险：来自两个案例的证据-加拿大蒙特利尔的对照研究

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Objective: To examine the risk of lung cancer among men associated with exposure to diesel engine emissions incurred in a wide range of occupations and industries. Methodology: 2 population-based lung cancer caseecontrol studies were conducted in Montreal. Study I (1979e1986) comprised 857 cases and 533 population controls; study II (1996e2001) comprised 736 cases and 894 population controls. A detailed job history was obtained, from which we inferred lifetime occupational exposure to 294 agents, including diesel engine emissions. ORs were estimated for each study and in the pooled data set, adjusting for sociodemographic factors, smoking history and selected occupational carcinogens. While it proved impossible to retrospectively estimate absolute exposure concentrations, there were estimates and analyses by relative measures of cumulative exposure. Results: Increased risks of lung cancer were found in both studies. The pooled analysis showed an OR of lung cancer associated with substantial exposure to diesel exhaust of 1.80 (95% CI 1.3 to 2.6). The risk associated with substantial exposure was higher for squamous cell carcinomas (OR 2.09; 95% CI 1.3 to 3.2) than other histological types. Joint effects between diesel exhaust exposure and tobacco smoking are compatible with a multiplicative synergistic effect. Discussion: Our findings provide further evidence supporting a causal link between diesel engine emissions and risk of lung cancer. The risk is stronger for the development of squamous cell carcinomas than for small cell tumours or adenocarcinomas.
机译：目的：研究与多种职业和行业接触的柴油发动机废气相关的男性患肺癌的风险。方法：在蒙特利尔进行了2项基于人群的肺癌病例对照研究。研究I（1979e1986）包括857例病例和533例人群对照。研究II（1996e2001）包括736例病例和894个人口对照。获得了详细的工作历史记录，从中可以推断出294种代理商的终生职业暴露，包括柴油机排放。对每项研究和汇总数据集中的OR进行了估算，并根据社会人口统计学因素，吸烟史和选定的职业致癌物进行了调整。虽然不可能回顾性地估计绝对暴露浓度，但可以通过累积暴露的相对量度进行估算和分析。结果：两项研究均发现肺癌风险增加。汇总分析显示，肺癌的OR值与大量暴露于柴油机废气中相关，为1.80（95％CI为1.3至2.6）。与其他组织学类型相比，鳞状细胞癌与大量暴露相关的风险更高（OR 2.09; 95％CI 1.3至3.2）。柴油机废气暴露与吸烟之间的联合效应与乘性协同效应相容。讨论：我们的发现提供了进一步的证据，支持了柴油机排放与肺癌风险之间的因果关系。鳞状细胞癌的发生风险比小细胞瘤或腺癌的发生风险要大。

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