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首页> 外文期刊>Occupational and environmental medicine >Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk.
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Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk.

机译：职业性日光照射，谷胱甘肽S-转移酶M1多态性和老年性白内障风险。

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BACKGROUND: The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage. OBJECTIVES: To examine whether the interaction of polymorphism of GSTM1 gene and occupational sunlight exposure modulate the risk of cataract. METHODS: Blood samples from 95 subjects with cataract and 95 age and sex matched healthy persons were collected. The genotypes of GSTM1 were determined using PCR. RESULTS: The null genotype of GSTM1 was associated with an increase in cataract risk in the indoor workplace, but this association was not significant in the outdoor subjects. CONCLUSION: The active genotype of GSTM1 has lost its protective role in persons who work outdoors. It is suggested that activity of the GSTmu enzyme may be inhibited in the human lens after occupational exposureto UV light.
机译：背景：白内障的发病机理受多种因素的影响，包括氧化应激。谷胱甘肽S-转移酶（GST）催化GST硫醇向亲电子受体的亲核加成。为了保护组织免受氧化损伤，对于异源生物排毒很重要。目的：研究GSTM1基因多态性与职业性日光照射之间的相互作用是否能调节白内障的风险。方法：收集了95例白内障患者和95例年龄和性别相匹配的健康人的血液样本。使用PCR确定GSTM1的基因型。结果：GSTM1的无效基因型与室内工作场所白内障风险增加相关，但在室外受试者中这种相关性并不显着。结论：GSTM1的活性基因型在户外工作的人中失去了保护作用。建议在职业性暴露于紫外线后，人晶状体中GSTmu酶的活性可能受到抑制。

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