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首页> 外文期刊>Occupational and environmental medicine >Occupational risks for adenocarcinoma of the nasal cavity and paranasal sinuses in the German wood industry.
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Occupational risks for adenocarcinoma of the nasal cavity and paranasal sinuses in the German wood industry.

机译：德国木材工业中的鼻腔和鼻旁窦腺癌的职业风险。

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OBJECTIVES: To examine the risk of wood dust and chemical exposures for adenocarcinoma of the nasal cavity and paranasal sinuses (ADCN) among German wood workers. METHODS: An industry-based case-control study with 86 male ADCN cases and 204 controls was conducted in the German wood-working industries. Cumulative and average wood-dust exposure was quantified with a job-exposure matrix based on wood-dust measurements at recent and historical workplaces. Probabilities of exposure to wood preservatives, stains, varnishes, and formaldehyde were semi-quantitatively rated. Odds ratios and 95% confidence intervals were calculated with logistic regression analysis conditional on age and adjusted for smoking and other factors. For estimating the risks of either wood dust or chemical additives, the authors additionally adjusted for the corresponding co-exposure. RESULTS: ADCN occurred relatively more frequently among wood workers that had ever worked as cabinet makers or joiners (OR 2.96, 95% CI 1.46 to 6.01) than as saw millers (OR 0.15, 95% CI 0.03 to 0.68). Average exposure to inhalable wood dust >/=5 mg/m(3) was associated with a high risk (OR 48.47, 95% CI 13.30 to 176.63) compared to levels below 3.5 mg/m(3). Assuming 40 years of exposure under these concentrations, the corresponding OR was 4.20 (95% CI 1.69 to 10.43). Exposure between 3.5 and 5 mg/m(3) was also found to pose a risk (OR 10.54, 95% CI 3.34 to 33.27). Exposure to pigment stains before 1970 was associated with an increased risk (OR 3.03; 95% CI 1.11 to 8.26). No significant associations were estimated for wood preservatives, varnishes, and formaldehyde. CONCLUSIONS: The authors found an elevated ADCN risk for exposure to inhalable wood dust above 3.5 mg/m(3). The rareness of the disease does not allow the exclusion of risk below that concentration. For pigment stains, there is evidence for an association of historical exposure with the development of ADCN in German wood workers.
机译：目的：检查在德国木工中，木材粉尘和化学物暴露对鼻腔和鼻旁窦（ADCN）腺癌的风险。方法：在德国木工行业进行了一项基于行业的病例对照研究，其中包括86例ADCN男性病例和204例对照。基于工作场所暴露矩阵，根据最近和历史工作场所的木屑测量值，对木屑的累积和平均暴露量进行了量化。对木材防腐剂，污渍，清漆和甲醛的暴露可能性进行了半定量评估。根据年龄进行logistic回归分析，计算吸烟率和95％置信区间，并根据吸烟和其他因素进行调整。为了估计木屑或化学添加剂的风险，作者还针对相应的共同暴露进行了调整。结果：ADCN在曾经作为橱柜制造商或细木工（OR 2.96，95％CI 1.46至6.01）的木工中发生的频率相对高于锯木厂（OR 0.15，95％CI 0.03至0.68）。与低于3.5 mg / m（3）的水平相比，平均可吸入木屑> / = 5 mg / m（3）的平均暴露与高风险（OR 48.47，95％CI 13.30至176.63）相关。假设在这些浓度下暴露40年，相应的OR为4.20（95％CI为1.69至10.43）。暴露在3.5和5 mg / m（3）之间也被发现有风险（OR 10.54，95％CI 3.34 to 33.27）。 1970年之前接触色素污渍会增加风险（OR 3.03; 95％CI 1.11至8.26）。估计木材防腐剂，清漆和甲醛之间无显着关联。结论：作者发现暴露于3.5 mg / m 3以上的可吸入木屑的ADCN风险升高。这种疾病的罕见性不允许排除低于该浓度的风险。对于颜料污渍，有证据表明历史暴露与德国木工中ADCN的发展有关。

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