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首页> 外文期刊>Occupational and environmental medicine >The upper midwest health study: Gliomas and occupational exposure to chlorinated solvents
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The upper midwest health study: Gliomas and occupational exposure to chlorinated solvents

机译：中西部上层健康研究：胶质瘤和职业性接触氯化溶剂

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Objectives: Occupational exposure to chlorinated aliphatic solvents has been associated with an increased cancer risk, including brain cancer. However, many of these solvents remain in active, large-volume use. We evaluated glioma risk from non-farm occupational exposure (everever and estimated cumulative exposure) to any of the six chlorinated solvents - carbon tetrachloride, chloroform, methylene chloride, trichloroethylene, tetrachloroethylene or 1,1,1-trichloroethane - among 798 cases and 1175 population-based controls, aged 18-80 years and non-metropolitan residents of Iowa, Michigan, Minnesota and Wisconsin. Methods Solvent use was estimated based on occupation, industry and era, using a bibliographic database of published exposure levels and exposure determinants. Unconditional logistic regression was used to calculate ORs adjusted for frequency matching variables age group and sex, and age and education. Additional analyses were limited to 904 participants who donated blood specimens (excluding controls reporting a previous diagnosis of cancer) genotyped for glutathione-S-transferases GSTP1, GSTM3 and GSTT1. Individuals with functional GST genes might convert chlorinated solvents crossing the blood-brain barrier into cytotoxic metabolites. Results: Both estimated cumulative exposure (ppm-years) and ever exposure to chlorinated solvents were associated with decreased glioma risk and were statistically significant overall and for women. In analyses comparing participants with a high probability of exposure with the unexposed, no associations were statistically significant. Solvent-exposed participants with functional GST genes were not at increased risk of glioma. Conclusions: We observed no associations of glioma risk and chlorinated solvent exposure. Large pooled studies are needed to explore the interaction of genetic pathways and environmental and occupational exposures in glioma aetiology.
机译：目标：职业性接触氯化脂肪族溶剂与癌症风险增加相关，包括脑癌。但是，这些溶剂中有许多仍保留大量使用的活性。我们评估了798例非农职业接触（永远/永远和估计的累积接触）六种氯化溶剂（四氯化碳，氯仿，二氯甲烷，三氯乙烯，四氯乙烯或1,1,1-三氯乙烷）中的胶质瘤风险。以及1175个以人口为基础的对照，年龄在18-80岁之间，是爱荷华州，密歇根州，明尼苏达州和威斯康星州的非大都市居民。方法根据职业，行业和时代，使用书目数据库（已公布的接触水平和接触决定因素）估算溶剂使用量。使用无条件logistic回归来计算针对年龄，性别，年龄和文化程度的频率匹配变量进行调整的OR。其他分析仅限于904位参与者，他们捐赠了针对谷胱甘肽S转移酶GSTP1，GSTM3和GSTT1进行基因分型的血液样本（不包括报告先前诊断为癌症的对照）。具有GST功能基因的个体可能会将穿过血脑屏障的氯化溶剂转化为细胞毒性代谢产物。结果：估计的累积暴露量（ppm-年）和曾经接触氯化溶剂都与神经胶质瘤风险降低有关，并且总体上和女性均具有统计学意义。在比较具有高暴露可能性和未暴露可能性的参与者的分析中，没有关联具有统计学意义。具有功能性GST基因的溶剂暴露参与者的神经胶质瘤风险没有增加。结论：我们观察到胶质瘤风险与氯化溶剂暴露无关联。需要大量的综合研究来探索神经胶质瘤病因中遗传途径与环境和职业接触的相互作用。

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